Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
1_MAEAP 6_ ASPAP 11_ LSPLE 16_ VELDP 21_ EFEPQ 26_ SRPRS 31_ CTWPL 36_ QRPEL 41_ QASPA 46_ KPSGE 51_ TAADS 56_ MIPEE 61_ EDDED 66_ DEDGG 71_ GRAGS 76_ AMAIG 81_ GGGGS 86_ GTLGS 91_ GLLLE 96_ DSARV 101_ LAPGG 106_ QDPGS 111_ GPATA 116_ AGGLS 121_ GGTQA 126_ LLQPQ 131_ QPLPP 136_ PQPGA 141_ AGGSG 146_ QPRKC 151_ SSRRN 156_ AWGNL 161_ SYADL 166_ ITRAI 171_ ESSPD 176_ KRLTL 181_ SQIYE 186_ WMVRC 191_ VPYFK 196_ DKGDS 201_ NSSAG 206_ WKNSI 211_ RHNLS 216_ LHSRF 221_ MRVQN 226_ EGTGK 231_ SSWWI 236_ INPDG 241_ GKSGK 246_ APRRR 251_ AVSMD 256_ NSNKY 261_ TKSRG 266_ RAAKK 271_ KAALQ 276_ TAPES 281_ ADDSP 286_ SQLSK 291_ WPGSP 296_ TSRSS 301_ DELDA 306_ WTDFR 311_ SRTNS 316_ NASTV 321_ SGRLS 326_ PIMAS 331_ TELDE 336_ VQDDD 341_ APLSP 346_ MLYSS 351_ SASLS 356_ PSVSK 361_ PCTVE 366_ LPRLT 371_ DMAGT 376_ MNLND 381_ GLTEN 386_ LMDDL 391_ LDNIT 396_ LPPSQ 401_ PSPTG 406_ GLMQR 411_ SSSFP 416_ YTTKG 421_ SGLGS 426_ PTSSF 431_ NSTVF 436_ GPSSL 441_ NSLRQ 446_ SPMQT 451_ IQENK 456_ PATFS 461_ SMSHY 466_ GNQTL 471_ QDLLT 476_ SDSLS 481_ HSDVM 486_ MTQSD 491_ PLMSQ 496_ ASTAV 501_ SAQNS 506_ RRNVM 511_ LRNDP 516_ MMSFA 521_ AQPNQ 526_ GSLVN 531_ QNLLH 536_ HQHQT 541_ QGALG 546_ GSRAL 551_ SNSVS 556_ NMGLS 561_ ESSSL 566_ GSAKH 571_ QQQSP 576_ VSQSM 581_ QTLSD 586_ SLSGS 591_ SLYST 596_ SANLP 601_ VMGHE 606_ KFPSD 611_ LDLDM 616_ FNGSL 621_ ECDME 626_ SIIRS 631_ ELMDA 636_ DGLDF 641_ NFDSL 646_ ISTQN 651_ VVGLN 656_ VGNFT 661_ GAKQA 666_SSQSW
1: Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302)