Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)
1_MGLKA 6_ RRAAG 11_ AAGGG 16_ GDGGG 21_ GGGGA 26_ ANPAG 31_ GDAAA 36_ AGDEE 41_ RKVGL 46_ APGDV 51_ EQVTL 56_ ALGAG 61_ ADKDG 66_ TLLLE 71_ GGGRD 76_ EGQRR 81_ TPQGI 86_ GLLAK 91_ TPLSR 96_ PVKRN 101_ NAKYR 106_ RIQTL 111_ IYDAL 116_ ERPRG 121_ WALLY 126_ HALVF 131_ LIVLG 136_ CLILA 141_ VLTTF 146_ KEYET 151_ VSGDW 156_ LLLLE 161_ TFAIF 166_ IFGAE 171_ FALRI 176_ WAAGC 181_ CCRYK 186_ GWRGR 191_ LKFAR 196_ KPLCM 201_ LDIFV 206_ LIASV 211_ PVVAV 216_ GNQGN 221_ VLATS 226_ LRSLR 231_ FLQIL 236_ RMLRM 241_ DRRGG 246_ TWKLL 251_ GSAIC 256_ AHSKE 261_ LITAW 266_ YIGFL 271_ TLILS 276_ SFLVY 281_ LVEKD 286_ VPEVD 291_ AQGEE 296_ MKEEF 301_ ETYAD 306_ ALWWG 311_ LITLA 316_ TIGYG 321_ DKTPK 326_ TWEGR 331_ LIAAT 336_ FSLIG 341_ VSFFA 346_ LPAGI 351_ LGSGL 356_ ALKVQ 361_ EQHRQ 366_ KHFEK 371_ RRKPA 376_ AELIQ 381_ AAWRY 386_ YATNP 391_ NRIDL 396_ VATWR 401_ FYESV 406_ VSFPF 411_ FRKEQ 416_ LEAAS 421_ SQKLG 426_ LLDRV 431_ RLSNP 436_ RGSNT 441_ KGKLF 446_ TPLNV 451_ DAIEE 456_ SPSKE 461_ PKPVG 466_ LNNKE 471_ RFRTA 476_ FRMKA 481_ YAFWQ 486_ SSEDA 491_ GTGDP 496_ MAEDR 501_ GYGND 506_ FPIED 511_ MIPTL 516_ KAAIR 521_ AVRIL 526_ QFRLY 531_ KKKFK 536_ ETLRP 541_ YDVKD 546_ VIEQY 551_ SAGHL 556_ DMLSR 561_ IKYLQ 566_ TRIDM 571_ IFTPG 576_ PPSTP 581_ KHKKS 586_ QKGSA 591_ FTFPS 596_ QQSPR 601_ NEPYV 606_ ARPST 611_ SEIED 616_ QSMMG 621_ KFVKV 626_ ERQVQ 631_ DMGKK 636_ LDFLV 641_ DMHMQ 646_ HMERL 651_ QVQVT 656_ EYYPT 661_ KGTSS 666_ PAEAE 671_ KKEDN 676_ RYSDL 681_ KTIIC 686_ NYSET 691_ GPPEP 696_ PYSFH 701_ QVTID 706_ KVSPY 711_ GFFAH 716_ DPVNL 721_ PRGGP 726_ SSGKV 731_ QATPP 736_ SSATT 741_ YVERP 746_ TVLPI 751_ LTLLD 756_ SRVSC 761_ HSQAD 766_ LQGPY 771_ SDRIS 776_ PRQRR 781_ SITRD 786_ SDTPL 791_ SLMSV 796_ NHEEL 801_ ERSPS 806_ GFSIS 811_ QDRDD 816_ YVFGP 821_ NGGSS 826_ WMREK 831_ RYLAE 836_ GETDT 841_ DTDPF 846_ TPSGS 851_ MPLSS 856_ TGDGI 861_ SDSVW 866_TPSNK
1: Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:16319223, PubMed:27564677, PubMed:28793216, PubMed:9872318). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:14534157, PubMed:16319223, PubMed:27564677, PubMed:9872318). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:16319223, PubMed:28793216). M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of M1 muscarinic acetylcholine receptors (PubMed:10713961). KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain (PubMed:11159685)