Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
1_MVQKS 6_ RNGGV 11_ YPGPS 16_ GEKKL 21_ KVGFV 26_ GLDPG 31_ APDST 36_ RDGAL 41_ LIAGS 46_ EAPKR 51_ GSILS 56_ KPRAG 61_ GAGAG 66_ KPPKR 71_ NAFYR 76_ KLQNF 81_ LYNVL 86_ ERPRG 91_ WAFIY 96_ HAYVF 101_ LLVFS 106_ CLVLS 111_ VFSTI 116_ KEYEK 121_ SSEGA 126_ LYILE 131_ IVTIV 136_ VFGVE 141_ YFVRI 146_ WAAGC 151_ CCRYR 156_ GWRGR 161_ LKFAR 166_ KPFCV 171_ IDIMV 176_ LIASI 181_ AVLAA 186_ GSQGN 191_ VFATS 196_ ALRSL 201_ RFLQI 206_ LRMIR 211_ MDRRG 216_ GTWKL 221_ LGSVV 226_ YAHSK 231_ ELVTA 236_ WYIGF 241_ LCLIL 246_ ASFLV 251_ YLAEK 256_ GENDH 261_ FDTYA 266_ DALWW 271_ GLITL 276_ TTIGY 281_ GDKYP 286_ QTWNG 291_ RLLAA 296_ TFTLI 301_ GVSFF 306_ ALPAG 311_ ILGSG 316_ FALKV 321_ QEQHR 326_ QKHFE 331_ KRRNP 336_ AAGLI 341_ QSAWR 346_ FYATN 351_ LSRTD 356_ LHSTW 361_ QYYER 366_ TVTVP 371_ MYSSQ 376_ TQTYG 381_ ASRLI 386_ PPLNQ 391_ LELLR 396_ NLKSK 401_ SGLAF 406_ RKDPP 411_ PEPSP 416_ SKGSP 421_ CRGPL 426_ CGCCP 431_ GRSSQ 436_ KVSLK 441_ DRVFS 446_ SPRGV 451_ AAKGK 456_ GSPQA 461_ QTVRR 466_ SPSAD 471_ QSLED 476_ SPSKV 481_ PKSWS 486_ FGDRS 491_ RARQA 496_ FRIKG 501_ AASRQ 506_ NSEEA 511_ SLPGE 516_ DIVDD 521_ KSCPC 526_ EFVTE 531_ DLTPG 536_ LKVSI 541_ RAVCV 546_ MRFLV 551_ SKRKF 556_ KESLR 561_ PYDVM 566_ DVIEQ 571_ YSAGH 576_ LDMLS 581_ RIKSL 586_ QSRVD 591_ QIVGR 596_ GPAIT 601_ DKDRT 606_ KGPAE 611_ AELPE 616_ DPSMM 621_ GRLGK 626_ VEKQV 631_ LSMEK 636_ KLDFL 641_ VNIYM 646_ QRMGI 651_ PPTET 656_ EAYFG 661_ AKEPE 666_ PAPPY 671_ HSPED 676_ SREHV 681_ DRHGC 686_ IVKIV 691_ RSSSS 696_ TGQKN 701_ FSAPP 706_ AAPPV 711_ QCPPS 716_ TSWQP 721_ QSHPR 726_ QGHGT 731_ SPVGD 736_ HGSLV 741_ RIPPP 746_ PAHER 751_ SLSAY 756_ GGGNR 761_ ASMEF 766_ LRQED 771_ TPGCR 776_ PPEGN 781_ LRDSD 786_ TSISI 791_ PSVDH 796_ EELER 801_ SFSGF 806_ SISQS 811_ KENLD 816_ ALNSC 821_ YAAVA 826_ PCAKV 831_ RPYIA 836_ EGESD 841_ TDSDL 846_ CTPCG 851_ PPPRS 856_ ATGEG 861_ PFGDV 866_GWAGP
1: Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961)