Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
1_MFRSK 6_ RSGLV 11_ RRLWR 16_ SRVVP 21_ DREEG 26_ GSGGG 31_ GGGDE 36_ DGSLG 41_ SRAEP 46_ APRAR 51_ EGGGC 56_ GRSEV 61_ RPVAP 66_ RRPRD 71_ AVGQR 76_ GAQGA 81_ GRRRR 86_ AGGPP 91_ RPMSE 96_ PGAGA 101_ GSSLL 106_ DVAEP 111_ GGPGW 116_ LPESD 121_ CETVT 126_ CCLFS 131_ ERDAA 136_ GAPRD 141_ ASDPL 146_ AGAAL 151_ EPAGG 156_ GRSRE 161_ ARSRL 166_ LLLEQ 171_ ELKTV 176_ TYSLL 181_ KRLKE 186_ RSLDT 191_ LLEAV 196_ ESRGG 201_ VPGGC 206_ VLVPR 211_ ADLRL 216_ GGQPA 221_ PPQLL 226_ LGRLF 231_ RWPDL 236_ QHAVE 241_ LKPLC 246_ GCHSF 251_ AAAAD 256_ GPTVC 261_ CNPYH 266_ FSRLC 271_ GPESP 276_ PPPYS 281_ RLSPR 286_ DEYKP 291_ LDLSD 296_ STLSY 301_ TETEA 306_ TNSLI 311_ TAPGE 316_ FSDAS 321_ MSPDA 326_ TKPSH 331_ WCSVA 336_ YWEHR 341_ TRVGR 346_ LYAVY 351_ DQAVS 356_ IFYDL 361_ PQGSG 366_ FCLGQ 371_ LNLEQ 376_ RSESV 381_ RRTRS 386_ KIGFG 391_ ILLSK 396_ EPDGV 401_ WAYNR 406_ GEHPI 411_ FVNSP 416_ TLDAP 421_ GGRAL 426_ VVRKV 431_ PPGYS 436_ IKVFD 441_ FERSG 446_ LQHAP 451_ EPDAA 456_ DGPYD 461_ PNSVR 466_ ISFAK 471_ GWGPC 476_ YSRQF 481_ ITSCP 486_ CWLEI 491_LLNNP
1: Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (PubMed:10647776, PubMed:10708948, PubMed:10708949, PubMed:16951688, PubMed:22275001, PubMed:30848080, PubMed:9436979, PubMed:9759503). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (PubMed:30848080, PubMed:9436979). Binds to regulatory elements in target promoter regions (PubMed:16491121)