DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)
1_MDLDL 6_ LDLNP 11_ RIIAA 16_ IKKAK 21_ LKSVK 26_ EVLHF 31_ SGPDL 36_ KRLTN 41_ LSSPE 46_ VWHLL 51_ RTASL 56_ HLRGS 61_ SILTA 66_ LQLHQ 71_ QKERF 76_ PTQHQ 81_ RLSLG 86_ CPVLD 91_ ALLRG 96_ GLPLD 101_ GITEL 106_ AGRSS 111_ AGKTQ 116_ LALQL 121_ CLAVQ 126_ FPRQH 131_ GGLEA 136_ GAVYI 141_ CTEDA 146_ FPHKR 151_ LQQLM 156_ AQQPR 161_ LRTDV 166_ PGELL 171_ QKLRF 176_ GSQIF 181_ IEHVA 186_ DVDTL 191_ LECVN 196_ KKVPV 201_ LLSRG 206_ MARLV 211_ VIDSV 216_ AAPFR 221_ CEFDS 226_ QASAP 231_ RARHL 236_ QSLGA 241_ TLREL 246_ SSAFQ 251_ SPVLC 256_ INQVT 261_ EAMEE 266_ QGAAH 271_ GPLGF 276_ WDERV 281_ SPALG 286_ ITWAN 291_ QLLVR 296_ LLADR 301_ LREEE 306_ AALGC 311_ PARTL 316_ RVLSA 321_ PHLPP 326_ SSCSY 331_ TISAE 336_ GVRGT 341_PGTQS
1: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C