DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)
1_MCSAF 6_ HRAES 11_ GTELL 16_ ARLEG 21_ RSSLK 26_ EIEPN 31_ LFADE 36_ DSPVH 41_ GDILE 46_ FHGPE 51_ GTGKT 56_ EMLYH 61_ LTARC 66_ ILPKS 71_ EGGLE 76_ VEVLF 81_ IDTDY 86_ HFDML 91_ RLVTI 96_ LEHRL 101_ SQSSE 106_ EIIKY 111_ CLGRF 116_ FLVYC 121_ SSSTH 126_ LLLTL 131_ YSLES 136_ MFCSH 141_ PSLCL 146_ LILDS 151_ LSAFY 156_ WIDRV 161_ NGGES 166_ VNLQE 171_ STLRK 176_ CSQCL 181_ EKLVN 186_ DYRLV 191_ LFATT 196_ QTIMQ 201_ KASSS 206_ SEEPS 211_ HASRR 216_ LCDVD 221_ IDYRP 226_ YLCKA 231_ WQQLV 236_ KHRMF 241_ FSKQD 246_ DSQSS 251_ NQFSL 256_ VSRCL 261_ KSNSL 266_ KKHFF 271_IIGES
1: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA