Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
1_MEESV 6_ VRPSV 11_ FVVDG 16_ QTDIP 21_ FTRLG 26_ RSHRR 31_ QSCSV 36_ ARVGL 41_ GLLLL 46_ LMGAG 51_ LAVQG 56_ WFLLQ 61_ LHWRL 66_ GEMVT 71_ RLPDG 76_ PAGSW 81_ EQLIQ 86_ ERRSH 91_ EVNPA 96_ AHLTG 101_ ANSSL 106_ TGSGG 111_ PLLWE 116_ TQLGL 121_ AFLRG 126_ LSYHD 131_ GALVV 136_ TKAGY 141_ YYIYS 146_ KVQLG 151_ GVGCP 156_ LGLAS 161_ TITHG 166_ LYKRT 171_ PRYPE 176_ ELELL 181_ VSQQS 186_ PCGRA 191_ TSSSR 196_ VWWDS 201_ SFLGG 206_ VVHLE 211_ AGEKV 216_ VVRVL 221_ DERLV 226_ RLRDG 231_TRSYF
1: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:10754304, PubMed:9462508). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304)