Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38)
1_MEEAI 6_ LVPCV 11_ LGLLL 16_ LPILA 21_ MLMAL 26_ CVHCH 31_ RLPGS 36_ YDSTS 41_ SDSLY 46_ PRGIQ 51_ FKRPH 56_ TVAPW 61_ PPAYP 66_ PVTSY 71_ PPLSQ 76_ PDLLP 81_ IPRSP 86_ QPLGG 91_ SHRTP 96_ SSRRD 101_ SDGAN 106_ SVASY 111_ ENEGA 116_ SGIRG 121_ AQAGW 126_ GVWGP 131_ SWTRL 136_ TPVSL 141_ PPEPA 146_ CEDAD 151_ EDEDD 156_ YHNPG 161_ YLVVL 166_ PDSTP 171_ ATSTA 176_ APSAP 181_ ALSTP 186_ GIRDS 191_ AFSME 196_ SIDDY 201_ VNVPE 206_ SGESA 211_ EASLD 216_ GSREY 221_ VNVSQ 226_ ELHPG 231_ AAKTE 236_ PAALS 241_ SQEAE 246_ EVEEE 251_ GAPDY 256_ENLQE
1: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules