Regulator of G-protein signaling 14 (RGS14)
1_MPGKP 6_ KHLGV 11_ PNGRM 16_ VLAVS 21_ DGELS 26_ STTGP 31_ QGQGE 36_ GRGSS 41_ LSIHS 46_ LPSGP 51_ SSPFP 56_ TEEQP 61_ VASWA 66_ LSFER 71_ LLQDP 76_ LGLAY 81_ FTEFL 86_ KKEFS 91_ AENVT 96_ FWKAC 101_ ERFQQ 106_ IPASD 111_ TQQLA 116_ QEARN 121_ IYQEF 126_ LSSQA 131_ LSPVN 136_ IDRQA 141_ WLGEE 146_ VLAEP 151_ RPDMF 156_ RAQQL 161_ QIFNL 166_ MKFDS 171_ YARFV 176_ KSPLY 181_ RECLL 186_ AEAEG 191_ RPLRE 196_ PGSSR 201_ LGSPD 206_ ATRKK 211_ PKLKP 216_ GKSLP 221_ LGVEE 226_ LGQLP 231_ PVEGP 236_ GGRPL 241_ RKSFR 246_ RELGG 251_ TANAA 256_ LRRES 261_ QGSLN 266_ SSASL 271_ DLGFL 276_ AFVSS 281_ KSESH 286_ RKSLG 291_ STEGE 296_ SESRP 301_ GKYCC 306_ VYLPD 311_ GTASL 316_ ALARP 321_ GLTIR 326_ DMLAG 331_ ICEKR 336_ GLSLP 341_ DIKVY 346_ LVGNE 351_ QALVL 356_ DQDCT 361_ VLADQ 366_ EVRLE 371_ NRITF 376_ ELELT 381_ ALERV 386_ VRISA 391_ KPTKR 396_ LQEAL 401_ QPILE 406_ KHGLS 411_ PLEVV 416_ LHRPG 421_ EKQPL 426_ DLGKL 431_ VSSVA 436_ AQRLV 441_ LDTLP 446_ GVKIS 451_ KARDK 456_ SPCRS 461_ QGCPP 466_ RTQDK 471_ ATHPP 476_ PASPS 481_ SLVKV 486_ PSSAT 491_ GKRQT 496_ CDIEG 501_ LVELL 506_ NRVQS 511_ SGAHD 516_ QRGLL 521_ RKEDL 526_ VLPEF 531_ LQLPA 536_ QGPSS 541_ EETPP 546_ QTKSA 551_ AQPIG 556_ GSLNS 561_TTDSA
1: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory