E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) (RING-type E3 ubiquitin transferase RNF13)
1_MLLSI 6_ GMLML 11_ SATQV 16_ YTILT 21_ VQLFA 26_ FLNLL 31_ PVEAD 36_ ILAYN 41_ FENAS 46_ QTFDD 51_ LPARF 56_ GYRLP 61_ AEGLK 66_ GFLIN 71_ SKPEN 76_ ACEPI 81_ VPPPV 86_ KDNSS 91_ GTFIV 96_ LIRRL 101_ DCNFD 106_ IKVLN 111_ AQRAG 116_ YKAAI 121_ VHNVD 126_ SDDLI 131_ SMGSN 136_ DIEVL 141_ KKIDI 146_ PSVFI 151_ GESSA 156_ NSLKD 161_ EFTYE 166_ KGGHL 171_ ILVPE 176_ FSLPL 181_ EYYLI 186_ PFLII 191_ VGICL 196_ ILIVI 201_ FMITK 206_ FVQDR 211_ HRARR 216_ NRLRK 221_ DQLKK 226_ LPVHK 231_ FKKGD 236_ EYDVC 241_ AICLD 246_ EYEDG 251_ DKLRI 256_ LPCSH 261_ AYHCK 266_ CVDPW 271_ LTKTK 276_ KTCPV 281_ CKQKV 286_ VPSQG 291_ DSDSD 296_ TDSSQ 301_ EENEV 306_ TEHTP 311_ LLRPL 316_ ASVSA 321_ QSFGA 326_ LSESR 331_ SHQNM 336_ TESSD 341_ YEEDD 346_ NEDTD 351_ SSDAE 356_ NEINE 361_ HDVVV 366_ QLQPN 371_ GERDY 376_NIANT
1: E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371). Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). Also involved in protein trafficking and localization (PubMed:24387786)