Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
1_MYRDP 6_ EAASP 11_ GAPSR 16_ DVLLV 21_ SAIIT 26_ VSLSV 31_ TVVLC 36_ GLCHW 41_ CQRKL 46_ GKRYK 51_ NSLET 56_ VGTPD 61_ SGRGR 66_ SEKKA 71_ IKLPA 76_ GGKAV 81_ NTAPV 86_ PGQTP 91_ HDESD 96_ RRTEP 101_ RSSVS 106_ DLVNS 111_ LTSEM 116_ LMLSP 121_ GSEED 126_ EAHEG 131_ CSREN 136_ LGRIQ 141_ FSVGY 146_ NFQES 151_ TLTVK 156_ IMKAQ 161_ ELPAK 166_ DFSGT 171_ SDPFV 176_ KIYLL 181_ PDKKH 186_ KLETK 191_ VKRKN 196_ LNPHW 201_ NETFL 206_ FEGFP 211_ YEKVV 216_ QRILY 221_ LQVLD 226_ YDRFS 231_ RNDPI 236_ GEVSI 241_ PLNKV 246_ DLTQM 251_ QTFWK 256_ DLKPC 261_ SDGSG 266_ SRGEL 271_ LLSLC 276_ YNPSA 281_ NSIIV 286_ NIIKA 291_ RNLKA 296_ MDIGG 301_ TSDPY 306_ VKVWL 311_ MYKDK 316_ RVEKK 321_ KTVTM 326_ KRNLN 331_ PIFNE 336_ SFAFD 341_ IPTEK 346_ LRETT 351_ IIITV 356_ MDKDK 361_ LSRND 366_ VIGKI 371_ YLSWK 376_ SGPGE 381_ VKHWK 386_ DMIAR 391_ PRQPV 396_AQWHQ
1: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity)