Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)
1_MAADI 6_ SESSG 11_ ADCKG 16_ DPRNS 21_ AKLDA 26_ DYPLR 31_ VLYCG 36_ VCSLP 41_ TEYCE 46_ YMPDV 51_ AKCRQ 56_ WLEKN 61_ FPNEF 66_ AKLTV 71_ ENSPK 76_ QEAGI 81_ SEGQG 86_ TAGEE 91_ EEKKK 96_ QKRGG 101_ RGQIK 106_ QKKKT 111_ VPQKV 116_ TIAKI 121_ PRAKK 126_ KYVTR 131_ VCGLA 136_ TFEID 141_ LKEAQ 146_ RFFAQ 151_ KFSCG 156_ ASVTG 161_ EDEII 166_ IQGDF 171_ TDDII 176_ DVIQE 181_ KWPEV 186_ DDDSI 191_EDLGE
1: Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent