Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
1_MMPQL 6_ QFKDA 11_ FWCRD 16_ FTAHT 21_ GYEVL 26_ LQRLL 31_ DGRKM 36_ CKDME 41_ ELLRQ 46_ RAQAE 51_ ERYGK 56_ ELVQI 61_ ARKAG 66_ GQTEI 71_ NSLRA 76_ SFDSL 81_ KQQME 86_ NVGSS 91_ HIQLA 96_ LTLRE 101_ ELRSL 106_ EEFRE 111_ RQKEQ 116_ RKKYE 121_ AVMDR 126_ VQKSK 131_ LSLYK 136_ KAMES 141_ KKTYE 146_ QKCRD 151_ ADDAE 156_ QAFER 161_ ISANG 166_ HQKQV 171_ EKSQN 176_ KARQC 181_ KDSAT 186_ EAERV 191_ YRQSI 196_ AQLEK 201_ VRAEW 206_ EQEHR 211_ TTCEA 216_ FQLQE 221_ FDRLT 226_ ILRNA 231_ LWVHS 236_ NQLSM 241_ QCVKD 246_ DELYE 251_ EVRLT 256_ LEGCS 261_ IDADI 266_ DSFIQ 271_ AKSTG 276_ TEPPA 281_ PVPYQ 286_ NYYDR 291_ EVTPL 296_ TSSPG 301_ IQPSC 306_ GMIKR 311_ FSGLL 316_ HGSPK 321_ TTSLA 326_ ASAAS 331_ TETLT 336_ PTPER 341_ NEGVY 346_ TAIAV 351_ QEIQG 356_ NPASP 361_ AQEYR 366_ ALYDY 371_ TAQNP 376_ DELDL 381_ SAGDI 386_ LEVIL 391_ EGEDG 396_ WWTVE 401_ RNGQR 406_ GFVPG 411_SYLEK
1: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils