Exportin-T (Exportin(tRNA)) (tRNA exportin)
1_MDEQA 6_ LLGLN 11_ PNADS 16_ DFRQR 21_ ALAYF 26_ EQLKI 31_ SPDAW 36_ QVCAE 41_ ALAQR 46_ TYSDD 51_ HVKFF 56_ CFQVL 61_ EHQVK 66_ YKYSE 71_ LTTVQ 76_ QQLIR 81_ ETLIS 86_ WLQAQ 91_ MLNPQ 96_ PEKTF 101_ IRNKA 106_ AQVFA 111_ LLFVT 116_ EYLTK 121_ WPKFF 126_ FDILS 131_ VVDLN 136_ PRGVD 141_ LYLRI 146_ LMAID 151_ SELVD 156_ RDVVH 161_ TSEEA 166_ RRNTL 171_ IKDTM 176_ REQCI 181_ PNLVE 186_ SWYQI 191_ LQNYQ 196_ FTNSE 201_ VTCQC 206_ LEVVG 211_ AYVSW 216_ IDLSL 221_ IANDR 226_ FINML 231_ LGHMS 236_ IEVLR 241_ EEACD 246_ CLFEV 251_ VNKGM 256_ DPVDK 261_ MKLVE 266_ SLCQV 271_ LQSAG 276_ FFSID 281_ QEEDV 286_ DFLAR 291_ FSKLV 296_ NGMGQ 301_ SLIVS 306_ WSKLI 311_ KNGDI 316_ KNAQE 321_ ALQAI 326_ ETKVA 331_ LMLQL 336_ LIHED 341_ DDISS 346_ NIIGF 351_ CYDYL 356_ HILKQ 361_ LTVLS 366_ DQQKA 371_ NVEAI 376_ MLAVM 381_ KKLTY 386_ DEEYN 391_ FENEG 396_ EDEAM 401_ FVEYR 406_ KQLKL 411_ LLDRL 416_ AQVSP 421_ ELLLA 426_ SVRRV 431_ FSSTL 436_ QNWQT 441_ TRFME 446_ VEVAI 451_ RLLYM 456_ LAEAL 461_ PVSHG 466_ AHFSG 471_ DVSKA 476_ SALQD 481_ MMRTL 486_ VTSGV 491_ SSYQH 496_ TSVTL 501_ EFFET 506_ VVRYE 511_ KFFTV 516_ EPQHI 521_ PCVLM 526_ AFLDH 531_ RGLRH 536_ SSAKV 541_ RSRTA 546_ YLFSR 551_ FVKSL 556_ NKQMN 561_ PFIED 566_ ILNRI 571_ QDLLE 576_ LSPPE 581_ NGHQS 586_ LLSSD 591_ DQLFI 596_ YETAG 601_ VLIVN 606_ SEYPA 611_ ERKQA 616_ LMRNL 621_ LTPLM 626_ EKFKI 631_ LLEKL 636_ MLAQD 641_ EERQA 646_ SLADC 651_ LNHAV 656_ GFASR 661_ TSKAF 666_ SNKQT 671_ VKQCG 676_ CSEVY 681_ LDCLQ 686_ TFLPA 691_ LSCPL 696_ QKDIL 701_ RSGVR 706_ TFLHR 711_ MIICL 716_ EEEVL 721_ PFIPS 726_ ASEHM 731_ LKDCE 736_ AKDLQ 741_ EFIPL 746_ INQIT 751_ AKFKI 756_ QVSPF 761_ LQQMF 766_ MPLLH 771_ AIFEV 776_ LLRPA 781_ EENDQ 786_ SAALE 791_ KQMLR 796_ RSYFA 801_ FLQTV 806_ TGSGM 811_ SEVIA 816_ NQGAE 821_ NVERV 826_ LVTVI 831_ QGAVE 836_ YPDPI 841_ AQKTC 846_ FIILS 851_ KLVEL 856_ WGGKD 861_ GPVGF 866_ ADFVY 871_ KHIVP 876_ ACFLA 881_ PLKQT 886_ FDLAD 891_ AQTVL 896_ ALSEC 901_ AVTLK 906_ TIHLK 911_ RGPEC 916_ VQYLQ 921_ QEYLP 926_ SLQVA 931_ PEIIQ 936_ EFCQA 941_ LQQPD 946_ AKVFK 951_ NYLKV 956_FFQRA
1: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus