Protein sprouty homolog 2 (Spry-2)
1_MEARA 6_ QSGNG 11_ SQPLL 16_ QTPRD 21_ GGRQR 26_ GEPDP 31_ RDALT 36_ QQVHV 41_ LSLDQ 46_ IRAIR 51_ NTNEY 56_ TEGPT 61_ VVPRP 66_ GLKPA 71_ PRPST 76_ QHKHE 81_ RLHGL 86_ PEHRQ 91_ PPRLQ 96_ HSQVH 101_ SSARA 106_ PLSRS 111_ ISTVS 116_ SGSRS 121_ STRTS 126_ TSSSS 131_ SEQRL 136_ LGSSF 141_ SSGPV 146_ ADGII 151_ RVQPK 156_ SELKP 161_ GELKP 166_ LSKED 171_ LGLHA 176_ YRCED 181_ CGKCK 186_ CKECT 191_ YPRPL 196_ PSDWI 201_ CDKQC 206_ LCSAQ 211_ NVIDY 216_ GTCVC 221_ CVKGL 226_ FYHCS 231_ NDDED 236_ NCADN 241_ PCSCS 246_ QSHCC 251_ TRWSA 256_ MGVMS 261_ LFLPC 266_ LWCYL 271_ PAKGC 276_ LKLCQ 281_ GCYDR 286_ VNRPG 291_ CRCKN 296_ SNTVC 301_ CKVPT 306_VPPRN
1: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561)