Gene name: DNPH1

Uniprot entry:

O43598

Protein names:

2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) (c-Myc-responsive protein RCL)

Protein sequence:

1_MAAAM 6_ VPGRS 11_ ESWER 16_ GEPGR 21_ PALYF 26_ CGSIR 31_ GGRED 36_ RTLYE 41_ RIVSR 46_ LRRFG 51_ TVLTE 56_ HVAAA 61_ ELGAR 66_ GEEAA 71_ GGDRL 76_ IHEQD 81_ LEWLQ 86_ QADVV 91_ VAEVT 96_ QPSLG 101_ VGYEL 106_ GRAVA 111_ FNKRI 116_ LCLFR 121_ PQSGR 126_ VLSAM 131_ IRGAA 136_ DGSRF 141_ QVWDY 146_ EEGEV 151_ EALLD 156_ RYFEA 161_ DPPGQ 166_VAASP

Protein annotations

Protein functions:

1: Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration (PubMed:33833118)