Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)
1_MELDF 6_ GHFDE 11_ RDKTS 16_ RNMRG 21_ SRMNG 26_ LPSPT 31_ HSAHC 36_ SFYRT 41_ RTLQA 46_ LSNEK 51_ KAKKV 56_ RFYRN 61_ GDRYF 66_ KGIVY 71_ AVSSD 76_ RFRSF 81_ DALLA 86_ DLTRS 91_ LSDNI 96_ NLPQG 101_ VRYIY 106_ TIDGS 111_ RKIGS 116_ MDELE 121_ EGESY 126_ VCSSD 131_ NFFKK 136_ VEYTK 141_ NVNPN 146_ WSVNV 151_ KTSAN 156_ MKAPQ 161_ SLASS 166_ NSAQA 171_ RENKD 176_ FVRPK 181_ LVTII 186_ RSGVK 191_ PRKAV 196_ RVLLN 201_ KKTAH 206_ SFEQV 211_ LTDIT 216_ EAIKL 221_ ETGVV 226_ KKLYT 231_ LDGKQ 236_ VTCLH 241_ DFFGD 246_ DDVFI 251_ ACGPE 256_ KFRYA 261_ QDDFS 266_ LDENE 271_ CRVMK 276_ GNPSA 281_ TAGPK 286_ ASPTP 291_ QKTSA 296_ KSPGP 301_ MRRSK 306_ SPADS 311_ GNDQD 316_ ANGTS 321_ SSQLS 326_ TPKSK 331_ QSPIS 336_ TPTSP 341_ GSLRK 346_ HKDLY 351_ LPLSL 356_DDSDS
1: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration