Protein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3)
1_MDAAV 6_ TDDFQ 11_ QILPI 16_ EQLRS 21_ THASN 26_ DYVER 31_ PPAPC 36_ KQALS 41_ SPSLI 46_ VQTHK 51_ SDWSL 56_ ATMPT 61_ SLPRS 66_ LSQCH 71_ QLQPL 76_ PQHLS 81_ QSSIA 86_ SSMSH 91_ STTAS 96_ DQRLL 101_ ASITP 106_ SPSGQ 111_ SIIRT 116_ QPGAG 121_ VHPKA 126_ DGALK 131_ GEAEQ 136_ SAGHP 141_ SEHLF 146_ ICEEC 151_ GRCKC 156_ VPCTA 161_ ARPLP 166_ SCWLC 171_ NQRCL 176_ CSAES 181_ LLDYG 186_ TCLCC 191_ VKGLF 196_ YHCST 201_ DDEDN 206_ CADEP 211_ CSCGP 216_ SSCFV 221_ RWAAM 226_ SLISL 231_ FLPCL 236_ CCYLP 241_ TRGCL 246_ HLCQQ 251_ GYDSL 256_ RRPGC 261_ RCKRH 266_ TNTVC 271_ RKISS 276_ GSAPF 281_PKAQE
1: Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049)