Orexin (Hypocretin) (Hcrt) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)]
1_MNLPS 6_ TKVSW 11_ AAVTL 16_ LLLLL 21_ LLPPA 26_ LLSSG 31_ AAAQP 36_ LPDCC 41_ RQKTC 46_ SCRLY 51_ ELLHG 56_ AGNHA 61_ AGILT 66_ LGKRR 71_ SGPPG 76_ LQGRL 81_ QRLLQ 86_ ASGNH 91_ AAGIL 96_ TMGRR 101_ AGAEP 106_ APRPC 111_ LGRRC 116_ SAPAA 121_ ASVAP 126_GGQSG
1: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested
2: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)
3: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)