Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)
1_MPRSF 6_ LVKKH 11_ FNASK 16_ KPNYS 21_ ELDTH 26_ TVIIS 31_ PYLYE 36_ SYSMP 41_ VIPQP 46_ EILSS 51_ GAYSP 56_ ITVWT 61_ TAAPF 66_ HAQLP 71_ NGLSP 76_ LSGYS 81_ SSLGR 86_ VSPPP 91_ PSDTS 96_ SKDHS 101_ GSESP 106_ ISDEE 111_ ERLQS 116_ KLSDP 121_ HAIEA 126_ EKFQC 131_ NLCNK 136_ TYSTF 141_ SGLAK 146_ HKQLH 151_ CDAQS 156_ RKSFS 161_ CKYCD 166_ KEYVS 171_ LGALK 176_ MHIRT 181_ HTLPC 186_ VCKIC 191_ GKAFS 196_ RPWLL 201_ QGHIR 206_ THTGE 211_ KPFSC 216_ PHCNR 221_ AFADR 226_ SNLRA 231_ HLQTH 236_ SDVKK 241_ YQCKN 246_ CSKTF 251_ SRMSL 256_ LHKHE 261_ESGCC
1: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis