Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1)
1_MDLLF 6_ GRRKT 11_ PEELL 16_ RQNQR 21_ ALNRA 26_ MRELD 31_ RERQK 36_ LETQE 41_ KKIIA 46_ DIKKM 51_ AKQGQ 56_ MDAVR 61_ IMAKD 66_ LVRTR 71_ RYVRK 76_ FVLMR 81_ ANIQA 86_ VSLKI 91_ QTLKS 96_ NNSMA 101_ QAMKG 106_ VTKAM 111_ GTMNR 116_ QLKLP 121_ QIQKI 126_ MMEFE 131_ RQAEI 136_ MDMKE 141_ EMMND 146_ AIDDA 151_ MGDEE 156_ DEEES 161_ DAVVS 166_ QVLDE 171_ LGLSL 176_ TDELS 181_ NLPST 186_ GGSLS 191_ VAAGG 196_ KKAEA 201_ AASAL 206_ ADADA 211_ DLEER 216_LKNLR
1: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4
2: (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release