Protein regulator of cytokinesis 1
1_MRRSE 6_ VLAEE 11_ SIVCL 16_ QKALN 21_ HLREI 26_ WELIG 31_ IPEDQ 36_ RLQRT 41_ EVVKK 46_ HIKEL 51_ LDMMI 56_ AEEES 61_ LKERL 66_ IKSIS 71_ VCQKE 76_ LNTLC 81_ SELHV 86_ EPFQE 91_ EGETT 96_ ILQLE 101_ KDLRT 106_ QVELM 111_ RKQKK 116_ ERKQE 121_ LKLLQ 126_ EQDQE 131_ LCEIL 136_ CMPHY 141_ DIDSA 146_ SVPSL 151_ EELNQ 156_ FRQHV 161_ TTLRE 166_ TKASR 171_ REEFV 176_ SIKRQ 181_ IILCM 186_ EALDH 191_ TPDTS 196_ FERDV 201_ VCEDE 206_ DAFCL 211_ SLENI 216_ ATLQK 221_ LLRQL 226_ EMQKS 231_ QNEAV 236_ CEGLR 241_ TQIRE 246_ LWDRL 251_ QIPEE 256_ EREAV 261_ ATIMS 266_ GSKAK 271_ VRKAL 276_ QLEVD 281_ RLEEL 286_ KMQNM 291_ KKVIE 296_ AIRVE 301_ LVQYW 306_ DQCFY 311_ SQEQR 316_ QAFAP 321_ FCAED 326_ YTESL 331_ LQLHD 336_ AEIVR 341_ LKNYY 346_ EVHKE 351_ LFEGV 356_ QKWEE 361_ TWRLF 366_ LEFER 371_ KASDP 376_ NRFTN 381_ RGGNL 386_ LKEEK 391_ QRAKL 396_ QKMLP 401_ KLEEE 406_ LKARI 411_ ELWEQ 416_ EHSKA 421_ FMVNG 426_ QKFME 431_ YVAEQ 436_ WEMHR 441_ LEKER 446_ AKQER 451_ QLKNK 456_ KQTET 461_ EMLYG 466_ SAPRT 471_ PSKRR 476_ GLAPN 481_ TPGKA 486_ RKLNT 491_ TTMSN 496_ ATANS 501_ SIRPI 506_ FGGTV 511_ YHSPV 516_ SRLPP 521_ SGSKP 526_ VAAST 531_ CSGKK 536_ TPRTG 541_ RHGAN 546_ KENLE 551_ LNGSI 556_ LSGGY 561_ PGSAP 566_ LQRNF 571_ SINSV 576_ ASTYS 581_ EFAKD 586_ PSLSD 591_ SSTVG 596_ LQREL 601_ SKASK 606_ SDATS 611_GILNS
1: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436)