Regulator of G-protein signaling 10 (RGS10)
1_MFNRA 6_ VSRLS 11_ RKRPP 16_ SDIHD 21_ SDGSS 26_ SSSHQ 31_ SLKST 36_ AKWAA 41_ SLENL 46_ LEDPE 51_ GVKRF 56_ REFLK 61_ KEFSE 66_ ENVLF 71_ WLACE 76_ DFKKM 81_ QDKTQ 86_ MQEKA 91_ KEIYM 96_ TFLSS 101_ KASSQ 106_ VNVEG 111_ QSRLN 116_ EKILE 121_ EPHPL 126_ MFQKL 131_ QDQIF 136_ NLMKY 141_ DSYSR 146_ FLKSD 151_ LFLKH 156_ KRTEE 161_ EEEDL 166_ PDAQT 171_ AAKRA 176_SRIYN
1: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10608901, PubMed:11443111, PubMed:18434541, PubMed:8774883, PubMed:9353196). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196)