BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207)
1_MGRKK 6_ KKQLK 11_ PWCWY 16_ CNRDF 21_ DDEKI 26_ LIQHQ 31_ KAKHF 36_ KCHIC 41_ HKKLY 46_ TGPGL 51_ AIHCM 56_ QVHKE 61_ TIDAV 66_ PNAIP 71_ GRTDI 76_ ELEIY 81_ GMEGI 86_ PEKDM 91_ DERRR 96_ LLEQK 101_ TQESQ 106_ KKKQQ 111_ DDSDE 116_ YDDDD 121_ SAAST 126_ SFQPQ 131_ PVQPQ 136_ QGYIP 141_ PMAQP 146_ GLPPV 151_ PGAPG 156_ MPPGI 161_ PPLMP 166_ GVPPL 171_ MPGMP 176_ PVMPG 181_ MPPGM 186_ MPMGG 191_ MMPPG 196_ PGIPP 201_ LMPGM 206_ PPGMP 211_ PPVPR 216_ PGIPP 221_ MTQAQ 226_ AVSAP 231_ GILNR 236_ PPAPT 241_ ATVPA 246_ PQPPV 251_ TKPLF 256_ PSAGQ 261_ MGTPV 266_ TSSST 271_ ASSNS 276_ ESLSA 281_ SSKAL 286_ FPSTA 291_ QAQAA 296_ VQGPV 301_ GTDFK 306_ PLNST 311_ PATTT 316_ EPPKP 321_ TFPAY 326_ TQSTA 331_ STTST 336_ TNSTA 341_ AKPAA 346_ SITSK 351_ PATLT 356_ TTSAT 361_ SKLIH 366_ PDEDI 371_ SLEER 376_ RAQLP 381_ KYQRN 386_ LPRPG 391_ QAPIG 396_ NPPVG 401_ PIGGM 406_ MPPQP 411_ GIPQQ 416_ QGMRP 421_ PMPPH 426_ GQYGG 431_ HHQGM 436_ PGYLP 441_ GAMPP 446_ YGQGP 451_ PMVPP 456_ YQGGP 461_ PRPPM 466_ GMRPP 471_VMSQG
1: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187)