Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)
1_MDTPE 6_ NVLQM 11_ LEAHM 16_ QSYKG 21_ NDPLG 26_ EWERY 31_ IQWVE 36_ ENFPE 41_ NKEYL 46_ ITLLE 51_ HLMKE 56_ FLDKK 61_ KYHND 66_ PRFIS 71_ YCLKF 76_ AEYNS 81_ DLHQF 86_ FEFLY 91_ NHGIG 96_ TLSSP 101_ LYIAW 106_ AGHLE 111_ AQGEL 116_ QHASA 121_ VLQRG 126_ IQNQA 131_ EPREF 136_ LQQQY 141_ RLFQT 146_ RLTET 151_ HLPAQ 156_ ARTSE 161_ PLHNV 166_ QVLNQ 171_ MITSK 176_ SNPGN 181_ NMACI 186_ SKNQG 191_ SELSG 196_ VISSA 201_ CDKES 206_ NMERR 211_ VITIS 216_ KSEYS 221_ VHSSL 226_ ASKVD 231_ VEQVV 236_ MYCKE 241_ KLIRG 246_ ESEFS 251_ FEELR 256_ AQKYN 261_ QRRKH 266_ EQWVN 271_ EDRHY 276_ MKRKE 281_ ANAFE 286_ EQLLK 291_ QKMDE 296_ LHKKL 301_ HQVVE 306_ TSHED 311_ LPASQ 316_ ERSEV 321_ NPARM 326_ GPSVG 331_ SQQEL 336_ RAPCL 341_ PVTYQ 346_ QTPVN 351_ MEKNP 356_ REAPP 361_ VVPPL 366_ ANAIS 371_ AALVS 376_ PATSQ 381_ SIAPP 386_ VPLKA 391_ QTVTD 396_ SMFAV 401_ ASKDA 406_ GCVNK 411_ STHEF 416_ KPQSG 421_ AEIKE 426_ GCETH 431_ KVANT 436_ SSFHT 441_ TPNTS 446_ LGMVQ 451_ ATPSK 456_ VQPSP 461_ TVHTK 466_ EALGF 471_ IMNMF 476_ QAPTL 481_ PDISD 486_ DKDEW 491_ QSLDQ 496_ NEDAF 501_ EAQFQ 506_ KNVRS 511_ SGAWG 516_ VNKII 521_ SSLSS 526_ AFHVF 531_ EDGNK 536_ ENYGL 541_ PQPKN 546_ KPTGA 551_ RTFGE 556_ RSVSR 561_ LPSKP 566_ KEEVP 571_ HAEEF 576_ LDDST 581_ VWGIR 586_ CNKTL 591_ APSPK 596_ SPGDF 601_ TSAAQ 606_ LASTP 611_ FHKLP 616_ VESVH 621_ ILEDK 626_ ENVVA 631_ KQCTQ 636_ ATLDS 641_ CEENM 646_ VVPSR 651_ DGKFS 656_ PIQEK 661_ SPKQA 666_ LSSHM 671_ YSASL 676_ LRLSQ 681_ PAAGG 686_ VLTCE 691_ AELGV 696_ EACRL 701_ TDTDA 706_ AIAED 711_ PPDAI 716_ AGLQA 721_ EWMQM 726_ SSLGT 731_ VDAPN 736_ FIVGN 741_ PWDDK 746_ LIFKL 751_ LSGLS 756_ KPVSS 761_ YPNTF 766_ EWQCK 771_ LPAIK 776_ PKTEF 781_ QLGSK 786_ LVYVH 791_ HLLGE 796_ GAFAQ 801_ VYEAT 806_ QGDLN 811_ DAKNK 816_ QKFVL 821_ KVQKP 826_ ANPWE 831_ FYIGT 836_ QLMER 841_ LKPSM 846_ QHMFM 851_ KFYSA 856_ HLFQN 861_ GSVLV 866_ GELYS 871_ YGTLL 876_ NAINL 881_ YKNTP 886_ EKVMP 891_ QGLVI 896_ SFAMR 901_ MLYMI 906_ EQVHD 911_ CEIIH 916_ GDIKP 921_ DNFIL 926_ GNGFL 931_ EQDDE 936_ DDLSA 941_ GLALI 946_ DLGQS 951_ IDMKL 956_ FPKGT 961_ IFTAK 966_ CETSG 971_ FQCVE 976_ MLSNK 981_ PWNYQ 986_ IDYFG 991_ VAATV 996_ YCMLF 1001_ GTYMK 1006_ VKNEG 1011_ GECKP 1016_ EGLFR 1021_ RLPHL 1026_ DMWNE 1031_ FFHVM 1036_ LNIPD 1041_ CHHLP 1046_ SLDLL 1051_ RQKLK 1056_ KVFQQ 1061_ HYTNK 1066_ IRALR 1071_ NRLIV 1076_LLLEC
1: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis