Mitotic checkpoint protein BUB3
1_MTGSN 6_ EFKLN 11_ QPPED 16_ GISSV 21_ KFSPN 26_ TSQFL 31_ LVSSW 36_ DTSVR 41_ LYDVP 46_ ANSMR 51_ LKYQH 56_ TGAVL 61_ DCAFY 66_ DPTHA 71_ WSGGL 76_ DHQLK 81_ MHDLN 86_ TDQEN 91_ LVGTH 96_ DAPIR 101_ CVEYC 106_ PEVNV 111_ MVTGS 116_ WDQTV 121_ KLWDP 126_ RTPCN 131_ AGTFS 136_ QPEKV 141_ YTLSV 146_ SGDRL 151_ IVGTA 156_ GRRVL 161_ VWDLR 166_ NMGYV 171_ QQRRE 176_ SSLKY 181_ QTRCI 186_ RAFPN 191_ KQGYV 196_ LSSIE 201_ GRVAV 206_ EYLDP 211_ SPEVQ 216_ KKKYA 221_ FKCHR 226_ LKENN 231_ IEQIY 236_ PVNAI 241_ SFHNI 246_ HNTFA 251_ TGGSD 256_ GFVNI 261_ WDPFN 266_ KKRLC 271_ QFHRY 276_ PTSIA 281_ SLAFS 286_ NDGTT 291_ LAIAS 296_ SYMYE 301_ MDDTE 306_ HPEDG 311_ IFIRQ 316_ VTDAE 321_TKPKS
1: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1