Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c)
1_MQRRW 6_ VFVLL 11_ DVLCL 16_ LVASL 21_ PFAIL 26_ TLVNA 31_ PYKRG 36_ FYCGD 41_ DSIRY 46_ PYRPD 51_ TITHG 56_ LMAGV 61_ TITAT 66_ VILVS 71_ AGEAY 76_ LVYTD 81_ RLYSR 86_ SDFNN 91_ YVAAV 96_ YKVLG 101_ TFLFG 106_ AAVSQ 111_ SLTDL 116_ AKYMI 121_ GRLRP 126_ NFLAV 131_ CDPDW 136_ SRVNC 141_ SVYVQ 146_ LEKVC 151_ RGNPA 156_ DVTEA 161_ RLSFY 166_ SGHSS 171_ FGMYC 176_ MVFLA 181_ LYVQA 186_ RLCWK 191_ WARLL 196_ RPTVQ 201_ FFLVA 206_ FALYV 211_ GYTRV 216_ SDYKH 221_ HWSDV 226_ LVGLL 231_ QGALV 236_ AALTV 241_ CYISD 246_ FFKAR 251_ PPQHC 256_ LKEEE 261_ LERKP 266_ SLSLT 271_ LTLGE 276_ ADHNH 281_YGYPH
1: Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:16467304, PubMed:9607309, PubMed:9705349). Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly (PubMed:16467304). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity)