Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)
1_MLSPK 6_ DILRK 11_ DLKLV 16_ HGYPM 21_ TCAFA 26_ SNWEK 31_ IEQFH 36_ SRPDD 41_ IVIAT 46_ YPKSG 51_ TTWVS 56_ EIIDM 61_ ILNDG 66_ DIEKC 71_ KRGFI 76_ TEKVP 81_ MLEMT 86_ LPGLR 91_ TSGIE 96_ QLEKN 101_ PSPRI 106_ VKTHL 111_ PTDLL 116_ PKSFW 121_ ENNCK 126_ MIYLA 131_ RNAKD 136_ VSVSY 141_ YHFDL 146_ MNNLQ 151_ PFPGT 156_ WEEYL 161_ EKFLT 166_ GKVAY 171_ GSWFT 176_ HVKNW 181_ WKKKE 186_ EHPIL 191_ FLYYE 196_ DMKEN 201_ PKEEI 206_ KKIIR 211_ FLEKN 216_ LNDEI 221_ LDRII 226_ HHTSF 231_ EVMKD 236_ NPLVN 241_ YTHLP 246_ TTVMD 251_ HSKSP 256_ FMRKG 261_ TAGDW 266_ KNYFT 271_ VAQNE 276_ KFDAI 281_ YETEM 286_ SKTAL 291_QFRTE
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440)