Alpha-actinin-4 (Non-muscle alpha-actinin 4)
1_MVDYH 6_ AANQS 11_ YQYGP 16_ SSAGN 21_ GAGGG 26_ GSMGD 31_ YMAQE 36_ DDWDR 41_ DLLLD 46_ PAWEK 51_ QQRKT 56_ FTAWC 61_ NSHLR 66_ KAGTQ 71_ IENID 76_ EDFRD 81_ GLKLM 86_ LLLEV 91_ ISGER 96_ LPKPE 101_ RGKMR 106_ VHKIN 111_ NVNKA 116_ LDFIA 121_ SKGVK 126_ LVSIG 131_ AEEIV 136_ DGNAK 141_ MTLGM 146_ IWTII 151_ LRFAI 156_ QDISV 161_ EETSA 166_ KEGLL 171_ LWCQR 176_ KTAPY 181_ KNVNV 186_ QNFHI 191_ SWKDG 196_ LAFNA 201_ LIHRH 206_ RPELI 211_ EYDKL 216_ RKDDP 221_ VTNLN 226_ NAFEV 231_ AEKYL 236_ DIPKM 241_ LDAED 246_ IVNTA 251_ RPDEK 256_ AIMTY 261_ VSSFY 266_ HAFSG 271_ AQKAE 276_ TAANR 281_ ICKVL 286_ AVNQE 291_ NEHLM 296_ EDYEK 301_ LASDL 306_ LEWIR 311_ RTIPW 316_ LEDRV 321_ PQKTI 326_ QEMQQ 331_ KLEDF 336_ RDYRR 341_ VHKPP 346_ KVQEK 351_ CQLEI 356_ NFNTL 361_ QTKLR 366_ LSNRP 371_ AFMPS 376_ EGKMV 381_ SDINN 386_ GWQHL 391_ EQAEK 396_ GYEEW 401_ LLNEI 406_ RRLER 411_ LDHLA 416_ EKFRQ 421_ KASIH 426_ EAWTD 431_ GKEAM 436_ LKHRD 441_ YETAT 446_ LSDIK 451_ ALIRK 456_ HEAFE 461_ SDLAA 466_ HQDRV 471_ EQIAA 476_ IAQEL 481_ NELDY 486_ YDSHN 491_ VNTRC 496_ QKICD 501_ QWDAL 506_ GSLTH 511_ SRREA 516_ LEKTE 521_ KQLEA 526_ IDQLH 531_ LEYAK 536_ RAAPF 541_ NNWME 546_ SAMED 551_ LQDMF 556_ IVHTI 561_ EEIEG 566_ LISAH 571_ DQFKS 576_ TLPDA 581_ DRERE 586_ AILAI 591_ HKEAQ 596_ RIAES 601_ NHIKL 606_ SGSNP 611_ YTTVT 616_ PQIIN 621_ SKWEK 626_ VQQLV 631_ PKRDH 636_ ALLEE 641_ QSKQQ 646_ SNEHL 651_ RRQFA 656_ SQANV 661_ VGPWI 666_ QTKME 671_ EIGRI 676_ SIEMN 681_ GTLED 686_ QLSHL 691_ KQYER 696_ SIVDY 701_ KPNLD 706_ LLEQQ 711_ HQLIQ 716_ EALIF 721_ DNKHT 726_ NYTME 731_ HIRVG 736_ WEQLL 741_ TTIAR 746_ TINEV 751_ ENQIL 756_ TRDAK 761_ GISQE 766_ QMQEF 771_ RASFN 776_ HFDKD 781_ HGGAL 786_ GPEEF 791_ KACLI 796_ SLGYD 801_ VENDR 806_ QGEAE 811_ FNRIM 816_ SLVDP 821_ NHSGL 826_ VTFQA 831_ FIDFM 836_ SRETT 841_ DTDTA 846_ DQVIA 851_ SFKVL 856_ AGDKN 861_ FITAE 866_ ELRRE 871_ LPPDQ 876_ AEYCI 881_ ARMAP 886_ YQGPD 891_ AVPGA 896_ LDYKS 901_ FSTAL 906_YGESD
1: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882)