Probable 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor)
1_MASRG 6_ RRPEH 11_ GGPPE 16_ LFYDE 21_ TEARK 26_ YVRNS 31_ RMIDI 36_ QTRMA 41_ GRALE 46_ LLYLP 51_ ENKPC 56_ YLLDI 61_ GCGTG 66_ LSGSY 71_ LSDEG 76_ HYWVG 81_ LDISP 86_ AMLDE 91_ AVDRE 96_ IEGDL 101_ LLGDM 106_ GQGIP 111_ FKPGT 116_ FDGCI 121_ SISAV 126_ QWLCN 131_ ANKKS 136_ ENPAK 141_ RLYCF 146_ FASLF 151_ SVLVR 156_ GSRAV 161_ LQLYP 166_ ENSEQ 171_ LELIT 176_ TQATK 181_ AGFSG 186_ GMVVD 191_ YPNSA 196_ KAKKF 201_ YLCLF 206_ SGPST 211_ FIPEG 216_ LSENQ 221_ DEVEP 226_ RESVF 231_ TNERF 236_ PLRMS 241_ RRGMV 246_ RKSRA 251_ WVLEK 256_ KERHR 261_ RQGRE 266_ VRPDT 271_ QYTGR 276_KRKPR
1: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492)