E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
1_MPPQL 6_ QETRM 11_ NRSIP 16_ VEVDE 21_ SEPYP 26_ SQLLK 31_ PIPEY 36_ SPEEE 41_ SEPPA 46_ PNIRN 51_ MAPNS 56_ LSAPT 61_ MLHNS 66_ SGDFS 71_ QAHST 76_ LKLAN 81_ HQRPV 86_ SRQVT 91_ CLRTQ 96_ VLEDS 101_ EDSFC 106_ RRHPG 111_ LGKAF 116_ PSGCS 121_ AVSEP 126_ ASESV 131_ VGALP 136_ AEHQF 141_ SFMEK 146_ RNQWL 151_ VSQLS 156_ AASPD 161_ TGHDS 166_ DKSDQ 171_ SLPNA 176_ SADSL 181_ GGSQE 186_ MVQRP 191_ QPHRN 196_ RAGLD 201_ LPTID 206_ TGYDS 211_ QPQDV 216_ LGIRQ 221_ LERPL 226_ PLTSV 231_ CYPQD 236_ LPRPL 241_ RSREF 246_ PQFEP 251_ QRYPA 256_ CAQML 261_ PPNLS 266_ PHAPW 271_ NYHYH 276_ CPGSP 281_ DHQVP 286_ YGHDY 291_ PRAAY 296_ QQVIQ 301_ PALPG 306_ QPLPG 311_ ASVRG 316_ LHPVQ 321_ KVILN 326_ YPSPW 331_ DHEER 336_ PAQRD 341_ CSFPG 346_ LPRHQ 351_ DQPHH 356_ QPPNR 361_ AGAPG 366_ ESLEC 371_ PAELR 376_ PQVPQ 381_ PPSPA 386_ AVPRP 391_ PSNPP 396_ ARGTL 401_ KTSNL 406_ PEELR 411_ KVFIT 416_ YSMDT 421_ AMEVV 426_ KFVNF 431_ LLVNG 436_ FQTAI 441_ DIFED 446_ RIRGI 451_ DIIKW 456_ MERYL 461_ RDKTV 466_ MIIVA 471_ ISPKY 476_ KQDVE 481_ GAESQ 486_ LDEDE 491_ HGLHT 496_ KYIHR 501_ MMQIE 506_ FIKQG 511_ SMNFR 516_ FIPVL 521_ FPNAK 526_ KEHVP 531_ TWLQN 536_ THVYS 541_ WPKNK 546_ KNILL 551_ RLLRE 556_ EEYVA 561_ PPRGP 566_LPTLQ
1: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828)