Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520)
1_MGSRS 6_ SHAAV 11_ IPDGD 16_ SIRRE 21_ TGFSQ 26_ ASLLR 31_ LHHRF 36_ RALDR 41_ NKKGY 46_ LSRMD 51_ LQQIG 56_ ALAVN 61_ PLGDR 66_ IIESF 71_ FPDGS 76_ QRVDF 81_ PGFVR 86_ VLAHF 91_ RPVED 96_ EDTET 101_ QDPKK 106_ PEPLN 111_ SRRNK 116_ LHYAF 121_ QLYDL 126_ DRDGK 131_ ISRHE 136_ MLQVL 141_ RLMVG 146_ VQVTE 151_ EQLEN 156_ IADRT 161_ VQEAD 166_ EDGDG 171_ AVSFV 176_ EFTKS 181_ LEKMD 186_ VEQKM 191_SIRIL
1: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus