Gene name: ENSA

Uniprot entry:

O43768

Protein names:

Alpha-endosulfine (ARPP-19e)

Protein sequence:

1_MSQKQ 6_ EEENP 11_ AEETG 16_ EEKQD 21_ TQEKE 26_ GILPE 31_ RAEEA 36_ KLKAK 41_ YPSLG 46_ QKPGG 51_ SDFLM 56_ KRLQK 61_ GQKYF 66_ DSGDY 71_ NMAKA 76_ KMKNK 81_ QLPSA 86_ GPDKN 91_ LVTGD 96_ HIPTP 101_ QDLPQ 106_ RKSSL 111_ VTSKL 116_AGGQV

Protein annotations

Protein functions:

1: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents