Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (Solute carrier family 25 member 20)
1_MADQP 6_ KPISP 11_ LKNLL 16_ AGGFG 21_ GVCLV 26_ FVGHP 31_ LDTVK 36_ VRLQT 41_ QPPSL 46_ PGQPP 51_ MYSGT 56_ FDCFR 61_ KTLFR 66_ EGITG 71_ LYRGM 76_ AAPII 81_ GVTPM 86_ FAVCF 91_ FGFGL 96_ GKKLQ 101_ QKHPE 106_ DVLSY 111_ PQLFA 116_ AGMLS 121_ GVFTT 126_ GIMTP 131_ GERIK 136_ CLLQI 141_ QASSG 146_ ESKYT 151_ GTLDC 156_ AKKLY 161_ QEFGI 166_ RGIYK 171_ GTVLT 176_ LMRDV 181_ PASGM 186_ YFMTY 191_ EWLKN 196_ IFTPE 201_ GKRVS 206_ ELSAP 211_ RILVA 216_ GGIAG 221_ IFNWA 226_ VAIPP 231_ DVLKS 236_ RFQTA 241_ PPGKY 246_ PNGFR 251_ DVLRE 256_ LIRDE 261_ GVTSL 266_ YKGFN 271_ AVMIR 276_ AFPAN 281_ AACFL 286_ GFEVA 291_ MKFLN 296_WATPN
1: Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable) (PubMed:12892634, PubMed:18307102). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102)