Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
1_MSRVP 6_ SPPPP 11_ AEMSS 16_ GPVAE 21_ SWCYT 26_ QIKVV 31_ KFSYM 36_ WTINN 41_ FSFCR 46_ EEMGE 51_ VIKSS 56_ TFSSG 61_ ANDKL 66_ KWCLR 71_ VNPKG 76_ LDEES 81_ KDYLS 86_ LYLLL 91_ VSCPK 96_ SEVRA 101_ KFKFS 106_ ILNAK 111_ GEETK 116_ AMESQ 121_ RAYRF 126_ VQGKD 131_ WGFKK 136_ FIRRD 141_ FLLDE 146_ ANGLL 151_ PDDKL 156_ TLFCE 161_ VSVVQ 166_ DSVNI 171_ SGQNT 176_ MNMVK 181_ VPECR 186_ LADEL 191_ GGLWE 196_ NSRFT 201_ DCCLC 206_ VAGQE 211_ FQAHK 216_ AILAA 221_ RSPVF 226_ SAMFE 231_ HEMEE 236_ SKKNR 241_ VEIND 246_ VEPEV 251_ FKEMM 256_ CFIYT 261_ GKAPN 266_ LDKMA 271_ DDLLA 276_ AADKY 281_ ALERL 286_ KVMCE 291_ DALCS 296_ NLSVE 301_ NAAEI 306_ LILAD 311_ LHSAD 316_ QLKTQ 321_ AVDFI 326_ NYHAS 331_ DVLET 336_ SGWKS 341_ MVVSH 346_ PHLVA 351_ EAYRS 356_ LASAQ 361_ CPFLG 366_PPRKR
1: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed:36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed:37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed:37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed:38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed:38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity)