Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3)
1_MTTQL 6_ GPALV 11_ LGVAL 16_ CLGCG 21_ QPLPQ 26_ VPERP 31_ FSVLW 36_ NVPSA 41_ HCEAR 46_ FGVHL 51_ PLNAL 56_ GIIAN 61_ RGQHF 66_ HGQNM 71_ TIFYK 76_ NQLGL 81_ YPYFG 86_ PRGTA 91_ HNGGI 96_ PQALP 101_ LDRHL 106_ ALAAY 111_ QIHHS 116_ LRPGF 121_ AGPAV 126_ LDWEE 131_ WCPLW 136_ AGNWG 141_ RRRAY 146_ QAASW 151_ AWAQQ 156_ VFPDL 161_ DPQEQ 166_ LYKAY 171_ TGFEQ 176_ AARAL 181_ MEDTL 186_ RVAQA 191_ LRPHG 196_ LWGFY 201_ HYPAC 206_ GNGWH 211_ SMASN 216_ YTGRC 221_ HAATL 226_ ARNTQ 231_ LHWLW 236_ AASSA 241_ LFPSI 246_ YLPPR 251_ LPPAH 256_ HQAFV 261_ RHRLE 266_ EAFRV 271_ ALVGH 276_ RHPLP 281_ VLAYV 286_ RLTHR 291_ RSGRF 296_ LSQDD 301_ LVQSI 306_ GVSAA 311_ LGAAG 316_ VVLWG 321_ DLSLS 326_ SSEEE 331_ CWHLH 336_ DYLVD 341_ TLGPY 346_ VINVT 351_ RAAMA 356_ CSHQR 361_ CHGHG 366_ RCARR 371_ DPGQM 376_ EAFLH 381_ LWPDG 386_ SLGDW 391_ KSFSC 396_ HCYWG 401_ WAGPT 406_ CQEPR 411_PGPKE
1: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro