A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)
1_MDQGY 6_ GGYGA 11_ WSAGP 16_ ANTQG 21_ AYGTG 26_ VASWQ 31_ GYENY 36_ NYYGA 41_ QNTSV 46_ TTGAT 51_ YSYGP 56_ ASWEA 61_ AKAND 66_ GGLAA 71_ GAPAM 76_ HMASY 81_ GPEPC 86_ TDNSD 91_ SLIAK 96_ INQRL 101_ DMMSK 106_ EGGRG 111_ GSGGG 116_ GEGIQ 121_ DRESS 126_ FRFQP 131_ FESYD 136_ SRPCL 141_ PEHNP 146_ YRPSY 151_ SYDYE 156_ FDLGS 161_ DRNGS 166_ FGGQY 171_ SECRD 176_ PARER 181_ GSLDG 186_ FMRGR 191_ GQGRF 196_ QDRSN 201_ PGTFM 206_ RSDPF 211_ VPPAA 216_ SSEPL 221_ STPWN 226_ ELNYV 231_ GGRGL 236_ GGPSP 241_ SRPPP 246_ SLFSQ 251_ SMAPD 256_ YGVMG 261_ MQGAG 266_ GYDST 271_ MPYGC 276_ GRSQP 281_ RMRDR 286_ DRPKR 291_ RGFDR 296_ FGPDG 301_ TGRKR 306_ KQFQL 311_ YEEPD 316_ TKLAR 321_ VDSEG 326_ DFSEN 331_ DDAAG 336_ DFRSG 341_ DEEFK 346_ GEDEL 351_ CDSGR 356_ QRGEK 361_ EDEDE 366_ DVKKR 371_ REKQR 376_ RRDRT 381_ RDRAA 386_ DRIQF 391_ ACSVC 396_ KFRSF 401_ DDEEI 406_ QKHLQ 411_ SKFHK 416_ ETLRF 421_ ISTKL 426_ PDKTV 431_ EFLQE 436_ YIVNR 441_ NKKIE 446_ KRRQE 451_ LMEKE 456_ TAKPK 461_ PDPFK 466_ GIGQE 471_ HFFKK 476_ IEAAH 481_ CLACD 486_ MLIPA 491_ QPQLL 496_ QRHLH 501_ SVDHN 506_ HNRRL 511_ AAEQF 516_ KKTSL 521_ HVAKS 526_ VLNNR 531_ HIVKM 536_ LEKYL 541_ KGEDP 546_ FTSET 551_ VDPEM 556_ EGDDN 561_ LGGED 566_ KKETP 571_ EEVAA 576_ DVLAE 581_ VITAA 586_ VRAVD 591_ GEGAP 596_ APESS 601_ GEPAE 606_ DEGPT 611_ DTAEA 616_ GSDPQ 621_ AEQLL 626_ EEQVP 631_ CGTAH 636_ EKGVP 641_ KARSE 646_ AAEAG 651_ NGAET 656_ MAAEA 661_ ESAQT 666_ RVAPA 671_ PAAAD 676_ AEVEQ 681_ TDAES 686_KDAVP
1: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity)