Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)
1_MAALS 6_ GVRWL 11_ TRALV 16_ SAGNP 21_ GAWRG 26_ LSTSA 31_ AAHAA 36_ SRSQA 41_ EDVRV 46_ EGSFP 51_ VTMLP 56_ GDGVG 61_ PELMH 66_ AVKEV 71_ FKAAA 76_ VPVEF 81_ QEHHL 86_ SEVQN 91_ MASEE 96_ KLEQV 101_ LSSMK 106_ ENKVA 111_ IIGKI 116_ HTPME 121_ YKGEL 126_ ASYDM 131_ RLRRK 136_ LDLFA 141_ NVVHV 146_ KSLPG 151_ YMTRH 156_ NNLDL 161_ VIIRE 166_ QTEGE 171_ YSSLE 176_ HESAR 181_ GVIEC 186_ LKIVT 191_ RAKSQ 196_ RIAKF 201_ AFDYA 206_ TKKGR 211_ GKVTA 216_ VHKAN 221_ IMKLG 226_ DGLFL 231_ QCCEE 236_ VAELY 241_ PKIKF 246_ ETMII 251_ DNCCM 256_ QLVQN 261_ PYQFD 266_ VLVMP 271_ NLYGN 276_ IIDNL 281_ AAGLV 286_ GGAGV 291_ VPGES 296_ YSAEY 301_ AVFET 306_ GARHP 311_ FAQAV 316_ GRNIA 321_ NPTAM 326_ LLSAS 331_ NMLRH 336_ LNLEY 341_ HSSMI 346_ ADAVK 351_ KVIKV 356_ GKVRT 361_ RDMGG 366_ YSTTT 371_ DFIKS 376_VIGHL
1: Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers