S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)
1_MSMPD 6_ AMPLP 11_ GVGEE 16_ LKQAK 21_ EIEDA 26_ EKYSF 31_ MATVT 36_ KAPKK 41_ QIQFA 46_ DDMQE 51_ FTKFP 56_ TKTGR 61_ RSLSR 66_ SISQS 71_ STDSY 76_ SSAAS 81_ YTDSS 86_ DDEVS 91_ PREKQ 96_ QTNSK 101_ GSSNF 106_ CVKNI 111_ KQAEF 116_ GRREI 121_ EIAEQ 126_ DMSAL 131_ ISLRK 136_ RAQGE 141_ KPLAG 146_ AKIVG 151_ CTHIT 156_ AQTAV 161_ LIETL 166_ CALGA 171_ QCRWS 176_ ACNIY 181_ STQNE 186_ VAAAL 191_ AEAGV 196_ AVFAW 201_ KGESE 206_ DDFWW 211_ CIDRC 216_ VNMDG 221_ WQANM 226_ ILDDG 231_ GDLTH 236_ WVYKK 241_ YPNVF 246_ KKIRG 251_ IVEES 256_ VTGVH 261_ RLYQL 266_ SKAGK 271_ LCVPA 276_ MNVND 281_ SVTKQ 286_ KFDNL 291_ YCCRE 296_ SILDG 301_ LKRTT 306_ DVMFG 311_ GKQVV 316_ VCGYG 321_ EVGKG 326_ CCAAL 331_ KALGA 336_ IVYIT 341_ EIDPI 346_ CALQA 351_ CMDGF 356_ RVVKL 361_ NEVIR 366_ QVDVV 371_ ITCTG 376_ NKNVV 381_ TREHL 386_ DRMKN 391_ SCIVC 396_ NMGHS 401_ NTEID 406_ VTSLR 411_ TPELT 416_ WERVR 421_ SQVDH 426_ VIWPD 431_ GKRVV 436_ LLAEG 441_ RLLNL 446_ SCSTV 451_ PTFVL 456_ SITAT 461_ TQALA 466_ LIELY 471_ NAPEG 476_ RYKQD 481_ VYLLP 486_ KKMDE 491_ YVASL 496_ HLPSF 501_ DAHLT 506_ ELTDD 511_ QAKYL 516_ GLNKN 521_GPFKP
1: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity)