Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]
1_MELEL 6_ DAGDQ 11_ DLLAF 16_ LLEES 21_ GDLGT 26_ APDEA 31_ VRAPL 36_ DWALP 41_ LSEVP 46_ SDWEV 51_ DDLLC 56_ SLLSP 61_ PASLN 66_ ILSSS 71_ NPCLV 76_ HHDHT 81_ YSLPR 86_ ETVSM 91_ DLESE 96_ SCRKE 101_ GTQMT 106_ PQHME 111_ ELAEQ 116_ EIARL 121_ VLTDE 126_ EKSLL 131_ EKEGL 136_ ILPET 141_ LPLTK 146_ TEEQI 151_ LKRVR 156_ RKIRN 161_ KRSAQ 166_ ESRRK 171_ KKVYV 176_ GGLES 181_ RVLKY 186_ TAQNM 191_ ELQNK 196_ VQLLE 201_ EQNLS 206_ LLDQL 211_ RKLQA 216_ MVIEI 221_ SNKTS 226_ SSSTC 231_ ILVLL 236_ VSFCL 241_ LLVPA 246_ MYSSD 251_ TRGSL 256_ PAEHG 261_ VLSRQ 266_ LRALP 271_ SEDPY 276_ QLELP 281_ ALQSE 286_ VPKDS 291_ THQWL 296_ DGSDC 301_ VLQAP 306_ GNTSC 311_ LLHYM 316_ PQAPS 321_ AEPPL 326_ EWPFP 331_ DLFSE 336_ PLCRG 341_ PILPL 346_ QANLT 351_ RKGGW 356_ LPTGS 361_ PSVIL 366_QDRYS
1: Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:10984507, PubMed:15845366, PubMed:16940180, PubMed:19779205, PubMed:9271389). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:15001559, PubMed:17296613, PubMed:19779205). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:17296613, PubMed:18587271)
2: (Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression
3: (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein
4: (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection
5: Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells
6: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3')
7: (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral promoters
8: (Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein