Gene name: PRICKLE3

Uniprot entry:

O43900

Protein names:

Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6)

Protein sequence:

1_MFARG 6_ SRRRR 11_ SGRAP 16_ PEAED 21_ PDRGQ 26_ PCNSC 31_ REQCP 36_ GFLLH 41_ GWRKI 46_ CQHCK 51_ CPREE 56_ HAVHA 61_ VPVDL 66_ ERIMC 71_ RLISD 76_ FQRHS 81_ ISDDD 86_ SGCAS 91_ EEYAW 96_ VPPGL 101_ KPEQV 106_ YQFFS 111_ CLPED 116_ KVPYV 121_ NSPGE 126_ KYRIK 131_ QLLHQ 136_ LPPHD 141_ SEAQY 146_ CTALE 151_ EEEKK 156_ ELRAF 161_ SQQRK 166_ RENLG 171_ RGIVR 176_ IFPVT 181_ ITGAI 186_ CEECG 191_ KQIGG 196_ GDIAV 201_ FASRA 206_ GLGAC 211_ WHPQC 216_ FVCTT 221_ CQELL 226_ VDLIY 231_ FYHVG 236_ KVYCG 241_ RHHAE 246_ CLRPR 251_ CQACD 256_ EIIFS 261_ PECTE 266_ AEGRH 271_ WHMDH 276_ FCCFE 281_ CEASL 286_ GGQRY 291_ VMRQS 296_ RPHCC 301_ ACYEA 306_ RHAEY 311_ CDGCG 316_ EHIGL 321_ DQGQM 326_ AYEGQ 331_ HWHAS 336_ DRCFC 341_ CSRCG 346_ RALLG 351_ RPFLP 356_ RRGLI 361_ FCSRA 366_ CSLGS 371_ EPTAP 376_ GPSRR 381_ SWSAG 386_ PVTAP 391_ LAAST 396_ ASFSA 401_ VKGAS 406_ ETTTK 411_ GTSTE 416_ LAPAT 421_ GPEEP 426_ SRFLR 431_ GAPHR 436_ HSMPE 441_ LGLRS 446_ VPEPP 451_ PESPG 456_ QPNLR 461_ PDDSA 466_ FGRQS 471_ TPRVS 476_ FRDPL 481_ VSEGG 486_ PRRTL 491_ SAPPA 496_ QRRRP 501_ RSPPP 506_ RAPSR 511_ RRHHH 516_ HNHHH 521_ HHNRH 526_ PSRRR 531_ HYQCD 536_ AGSGS 541_ DSESC 546_ SSSPS 551_ SSSSE 556_ SSEDD 561_ GFFLG 566_ ERIPL 571_ PPHLC 576_ RPMPA 581_ QDTAM 586_ ETFNS 591_ PSLSL 596_ PRDSR 601_ AGMPR 606_QARDK

Protein annotations

Protein functions:

1: Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135)