Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3)
1_MTGYT 6_ MLRNG 11_ GAGNG 16_ GQTCM 21_ LRWSN 26_ RIRLT 31_ WLSFT 36_ LFVIL 41_ VFFPL 46_ IAHYY 51_ LTTLD 56_ EADEA 61_ GKRIF 66_ GPRVG 71_ NELCE 76_ VKHVL 81_ DLCRI 86_ RESVS 91_ EELLQ 96_ LEAKR 101_ QELNS 106_ EIAKL 111_ NLKIE 116_ ACKKS 121_ IENAK 126_ QDLLQ 131_ LKNVI 136_ SQTEH 141_ SYKEL 146_ MAQNQ 151_ PKLSL 156_ PIRLL 161_ PEKDD 166_ AGLPP 171_ PKATR 176_ GCRLH 181_ NCFDY 186_ SRCPL 191_ TSGFP 196_ VYVYD 201_ SDQFV 206_ FGSYL 211_ DPLVK 216_ QAFQA 221_ TARAN 226_ VYVTE 231_ NADIA 236_ CLYVI 241_ LVGEM 246_ QEPVV 251_ LRPAE 256_ LEKQL 261_ YSLPH 266_ WRTDG 271_ HNHVI 276_ INLSR 281_ KSDTQ 286_ NLLYN 291_ VSTGR 296_ AMVAQ 301_ STFYT 306_ VQYRP 311_ GFDLV 316_ VSPLV 321_ HAMSE 326_ PNFME 331_ IPPQV 336_ PVKRK 341_ YLFTF 346_ QGEKI 351_ ESLRS 356_ SLQEA 361_ RSFEE 366_ EMEGD 371_ PPADY 376_ DDRII 381_ ATLKA 386_ VQDSK 391_ LDQVL 396_ VEFTC 401_ KNQPK 406_ PSLPT 411_ EWALC 416_ GERED 421_ RLELL 426_ KLSTF 431_ ALIIT 436_ PGDPR 441_ LVISS 446_ GCATR 451_ LFEAL 456_ EVGAV 461_ PVVLG 466_ EQVQL 471_ PYQDM 476_ LQWNE 481_ AALVV 486_ PKPRV 491_ TEVHF 496_ LLRSL 501_ SDSDL 506_ LAMRR 511_ QGRFL 516_ WETYF 521_ STADS 526_ IFNTV 531_ LAMIR 536_ TRIQI 541_ PAAPI 546_ REEAA 551_ AEIPH 556_ RSGKA 561_ AGTDP 566_ NMADN 571_ GDLDL 576_ GPVET 581_ EPPYA 586_ SPRYL 591_ RNFTL 596_ TVTDF 601_ YRSWN 606_ CAPGP 611_ FHLFP 616_ HTPFD 621_ PVLPS 626_ EAKFL 631_ GSGTG 636_ FRPIG 641_ GGAGG 646_ SGKEF 651_ QAALG 656_ GNVPR 661_ EQFTV 666_ VMLTY 671_ EREEV 676_ LMNSL 681_ ERLNG 686_ LPYLN 691_ KVVVV 696_ WNSPK 701_ LPSED 706_ LLWPD 711_ IGVPI 716_ MVVRT 721_ EKNSL 726_ NNRFL 731_ PWNEI 736_ ETEAI 741_ LSIDD 746_ DAHLR 751_ HDEIM 756_ FGFRV 761_ WREAR 766_ DRIVG 771_ FPGRY 776_ HAWDI 781_ PHQSW 786_ LYNSN 791_ YSCEL 796_ SMVLT 801_ GAAFF 806_ HKYYA 811_ YLYSY 816_ VMPQA 821_ IRDMV 826_ DEYIN 831_ CEDIA 836_ MNFLV 841_ SHITR 846_ KPPIK 851_ VTSRW 856_ TFRCP 861_ GCPQA 866_ LSHDD 871_ SHFHE 876_ RHKCI 881_ NFFVK 886_ VYGYM 891_ PLLYT 896_ QFRVD 901_ SVLFK 906_ TRLPH 911_DKTKC
1: Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS) (PubMed:28132690, PubMed:28148688). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker (PubMed:11390981, PubMed:35676258). May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity) (PubMed:11390981, PubMed:35676258). Lacks glucuronyl transferase II (GlcAT-II) activity (PubMed:11390981, PubMed:35676258). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:11390981, PubMed:22727489, PubMed:28132690, PubMed:28148688, PubMed:35676258). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion (By similarity)
2: Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway (PubMed:22727489, PubMed:27830702, PubMed:34099862). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489). Required for the inhibition of skin inflammation mediated by REG3A through the activation of PI3K-AKT-STAT3 pathway (PubMed:27830702). Required for the function of REG3A and REG3G in glucose tolerance in pancreas (PubMed:19158046). Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death (By similarity)