Ephrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L)
1_MAPAQ 6_ RPLLP 11_ LLLLL 16_ LPLPP 21_ PPFAR 26_ AEDAA 31_ RANSD 36_ RYAVY 41_ WNRSN 46_ PRFHA 51_ GAGDD 56_ GGGYT 61_ VEVSI 66_ NDYLD 71_ IYCPH 76_ YGAPL 81_ PPAER 86_ MEHYV 91_ LYMVN 96_ GEGHA 101_ SCDHR 106_ QRGFK 111_ RWECN 116_ RPAAP 121_ GGPLK 126_ FSEKF 131_ QLFTP 136_ FSLGF 141_ EFRPG 146_ HEYYY 151_ ISATP 156_ PNAVD 161_ RPCLR 166_ LKVYV 171_ RPTNE 176_ TLYEA 181_ PEPIF 186_ TSNNS 191_ CSSPG 196_ GCRLF 201_ LSTIP 206_VLWTL
1: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity)