Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)
1_MSAKD 6_ ERARE 11_ ILRGF 16_ KLNWM 21_ NLRDA 26_ ETGKI 31_ LWQGT 36_ EDLSV 41_ PGVEH 46_ EARVP 51_ KKILK 56_ CKAVS 61_ RELNF 66_ SSTEQ 71_ MEKFR 76_ LEQKV 81_ YFKGQ 86_ CLEEW 91_ FFEFG 96_ FVIPN 101_ STNTW 106_ QSLIE 111_ AAPES 116_ QMMPA 121_ SVLTG 126_ NVIIE 131_ TKFFD 136_ DDLLV 141_STSRV
1: Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Required for RAB28 localization to the cone cell outer segments in the retina (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity)