Origin recognition complex subunit 4
1_MSSRK 6_ SKSNS 11_ LIHTE 16_ CLSQV 21_ QRILR 26_ ERFCR 31_ QSPHS 36_ NLFGV 41_ QVQYK 46_ HLSEL 51_ LKRTA 56_ LHGES 61_ NSVLI 66_ IGPRG 71_ SGKTM 76_ LINHA 81_ LKELM 86_ EIEEV 91_ SENVL 96_ QVHLN 101_ GLLQI 106_ NDKIA 111_ LKEIT 116_ RQLNL 121_ ENVVG 126_ DKVFG 131_ SFAEN 136_ LSFLL 141_ EALKK 146_ GDRTS 151_ SCPVI 156_ FILDE 161_ FDLFA 166_ HHKNQ 171_ TLLYN 176_ LFDIS 181_ QSAQT 186_ PIAVI 191_ GLTCR 196_ LDILE 201_ LLEKR 206_ VKSRF 211_ SHRQI 216_ HLMNS 221_ FGFPQ 226_ YVKIF 231_ KEQLS 236_ LPAEF 241_ PDKVF 246_ AEKWN 251_ ENVQY 256_ LSEDR 261_ SVQEV 266_ LQKHF 271_ NISKN 276_ LRSLH 281_ MLLML 286_ ALNRV 291_ TASHP 296_ FMTAV 301_ DLMEA 306_ SQLCS 311_ MDSKA 316_ NIVHG 321_ LSVLE 326_ ICLII 331_ AMKHL 336_ NDIYE 341_ EEPFN 346_ FQMVY 351_ NEFQK 356_ FVQRK 361_ AHSVY 366_ NFEKP 371_ VVMKA 376_ FEHLQ 381_ QLELI 386_ KPMER 391_ TSGNS 396_ QREYQ 401_ LMKLL 406_ LDNTQ 411_ IMNAL 416_ QKYPN 421_ CPTDV 426_ RQWAT 431_SSLSW
1: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3