Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)]
1_MFYAH 6_ FVLSK 11_ RGPLA 16_ KIWLA 21_ AHWDK 26_ KLTKA 31_ HVFEC 36_ NLESS 41_ VESII 46_ SPKVK 51_ MALRT 56_ SGHLL 61_ LGVVR 66_ IYHRK 71_ AKYLL 76_ ADCNE 81_ AFIKI 86_ KMAFR 91_ PGVVD 96_ LPEEN 101_ REAAY 106_ NAITL 111_ PEEFH 116_ DFDQP 121_ LPDLD 126_ DIDVA 131_ QQFSL 136_ NQSRV 141_ EEITM 146_ REEVG 151_ NISIL 156_ QENDF 161_ GDFGM 166_ DDREI 171_ MREGS 176_ AFEDD 181_ DMLVS 186_ TTTSN 191_ LLLES 196_ EQSTS 201_ NLNEK 206_ INHLE 211_ YEDQY 216_ KDDNF 221_ GEGND 226_ GGILD 231_ DKLIS 236_ NNDGG 241_ IFDDP 246_ PALSE 251_ AGVML 256_ PEQPA 261_ HDDMD 266_ EDDNV 271_ SMGGP 276_ DSPDS 281_ VDPVE 286_ PMPTM 291_ TDQTT 296_ LVPNE 301_ EEAFA 306_ LEPID 311_ ITVKE 316_ TKAKR 321_ KRKLI 326_ VDSVK 331_ ELDSK 336_ TIRAQ 341_ LSDYS 346_ DIVTT 351_ LDLAP 356_ PTKKL 361_ MMWKE 366_ TGGVE 371_ KLFSL 376_ PAQPL 381_ WNNRL 386_ LKLFT 391_ RCLTP 396_ LVPED 401_ LRKRR 406_ KGGEA 411_ DNLDE 416_ FLKEF 421_ ENPEV 426_ PREDQ 431_ QQQHQ 436_ QRDVI 441_ DEPII 446_ EEPSR 451_ LQESV 456_ MEASR 461_ TNIDE 466_ SAMPP 471_ PPPQG 476_ VKRKA 481_ GQIDP 486_ EPVMP 491_ PQQVE 496_ QMEIP 501_ PVELP 506_ PEEPP 511_ NICQL 516_ IPELE 521_ LLPEK 526_ EKEKE 531_ KEKED 536_ DEEEE 541_ DEDAS 546_ GGDQD 551_ QEERR 556_ WNKRT 561_ QQMLH 566_ GLQRA 571_ LAKTG 576_ AESIS 581_ LLELC 586_ RNTNR 591_ KQAAA 596_ KFYSF 601_ LVLKK 606_ QQAIE 611_ LTQEE 616_ PYSDI 621_ IATPG 626_PRFHI
1: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity)
2: May promote apoptosis