Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)
1_MATFV 6_ ELSTK 11_ AKMPI 16_ VGLGT 21_ WKSPL 26_ GKVKE 31_ AVKVA 36_ IDAGY 41_ RHIDC 46_ AYVYQ 51_ NEHEV 56_ GEAIQ 61_ EKIQE 66_ KAVKR 71_ EDLFI 76_ VSKLW 81_ PTFFE 86_ RPLVR 91_ KAFEK 96_ TLKDL 101_ KLSYL 106_ DVYLI 111_ HWPQG 116_ FKSGD 121_ DLFPK 126_ DDKGN 131_ AIGGK 136_ ATFLD 141_ AWEAM 146_ EELVD 151_ EGLVK 156_ ALGVS 161_ NFSHF 166_ QIEKL 171_ LNKPG 176_ LKYKP 181_ VTNQV 186_ ECHPY 191_ LTQEK 196_ LIQYC 201_ HSKGI 206_ TVTAY 211_ SPLGS 216_ PDRPW 221_ AKPED 226_ PSLLE 231_ DPKIK 236_ EIAAK 241_ HKKTA 246_ AQVLI 251_ RFHIQ 256_ RNVIV 261_ IPKSV 266_ TPARI 271_ VENIQ 276_ VFDFK 281_ LSDEE 286_ MATIL 291_ SFNRN 296_ WRACN 301_ VLQSS 306_ HLEDY 311_PFNAE
1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097)