Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
1_MTDRF 6_ WDQWY 11_ LWYLR 16_ LLRLL 21_ DRGSF 26_ RNDGL 31_ KASDV 36_ LPILK 41_ EKVAF 46_ VSGGR 51_ DKRGG 56_ PILTF 61_ PARSN 66_ HDRIR 71_ QEDLR 76_ KLVTY 81_ LASVP 86_ SEDVC 91_ KRGFT 96_ VIIDM 101_ RGSKW 106_ DLIKP 111_ LLKTL 116_ QEAFP 121_ AEIHV 126_ ALIIK 131_ PDNFW 136_ QKQKT 141_ NFGSS 146_ KFIFE 151_ TSMVS 156_ VEGLT 161_ KLVDP 166_ SQLTE 171_ EFDGS 176_ LDYNH 181_ EEWIE 186_ LRLSL 191_ EEFFN 196_ SAVHL 201_ LSRLE 206_ DLQEM 211_ LARKE 216_ FPVDV 221_ EGSRR 226_ LIDEH 231_ TQLKK 236_ KVLKA 241_ PVEEL 246_ DREGQ 251_ RLLQC 256_ IRCSD 261_ GFSGR 266_ NCIPG 271_ SADFQ 276_ SLVPK 281_ ITSLL 286_ DKLHS 291_ TRQHL 296_ HQMWH 301_ VRKLK 306_ LDQCF 311_ QLRLF 316_ EQDAE 321_ KMFDW 326_ ISHNK 331_ ELFLQ 336_ SHTEI 341_ GVSYQ 346_ YALDL 351_ QTQHN 356_ HFAMN 361_ SMNAY 366_ VNINR 371_ IMSVA 376_ SRLSE 381_ AGHYA 386_ SQQIK 391_ QISTQ 396_ LDQEW 401_ KSFAA 406_ ALDER 411_ STILA 416_ MSAVF 421_ HQKAE 426_ QFLSG 431_ VDAWC 436_ KMCSE 441_ GGLPS 446_ EMQDL 451_ ELAIH 456_ HHQTL 461_ YEQVT 466_ QAYTE 471_ VSQDG 476_ KALLD 481_ VLQRP 486_ LSPGN 491_ SESLT 496_ ATANY 501_ SKAVH 506_ QVLDV 511_ VHEVL 516_ HHQRR 521_ LESIW 526_ QHRKV 531_ RLHQR 536_ LQLCV 541_ FQQDV 546_ QQVLD 551_ WIENH 556_ GEAFL 561_ SKHTG 566_ VGKSL 571_ HRARA 576_ LQKRH 581_ DDFEE 586_ VAQNT 591_ YTNAD 596_ KLLEA 601_ AEQLA 606_ QTGEC 611_ DPEEI 616_ YKAAR 621_ HLEVR 626_ IQDFV 631_ RRVEQ 636_ RKLLL 641_ DMSVS 646_ FHTHT 651_ KELWT 656_ WMEDL 661_ QKEML 666_ EDVCA 671_ DSVDA 676_ VQELI 681_ KQFQQ 686_ QQTAT 691_ LDATL 696_ NVIKE 701_ GEDLI 706_ QQLRS 711_ APPSL 716_ GEPSE 721_ ARDSA 726_ VSNNK 731_ TPHSS 736_ SISHI 741_ ESVLQ 746_ QLDDA 751_ QVQME 756_ ELFHE 761_ RKIKL 766_ DIFLQ 771_ LRIFE 776_ QYTIE 781_ VTAEL 786_ DAWNE 791_ DLLRQ 796_ MNDFN 801_ TEDLT 806_ LAEQR 811_ LQRHT 816_ ERKLA 821_ MNNMT 826_ FEVIQ 831_ QGQDL 836_ HQYIT 841_ EVQAS 846_ GIELI 851_ CEKDI 856_ DLAAQ 861_ VQELL 866_ EFLHE 871_ KQHEL 876_ ELNAE 881_ QTHKR 886_ LEQCL 891_ QLRHL 896_ QAEVK 901_ QVLGW 906_ IRNGE 911_ SMLNA 916_ SLVNA 921_ SSLSE 926_ AEQLQ 931_ REHEQ 936_ FQLAI 941_ ESLFH 946_ ATSLQ 951_ KTHQS 956_ ALQVQ 961_ QKAEV 966_ LLQAG 971_ HYDAD 976_ AIREC 981_ AEKVA 986_ LHWQQ 991_ LMLKM 996_ EDRLK 1001_ LVNAS 1006_ VAFYK 1011_ TSEQV 1016_ CSVLE 1021_ SLEQE 1026_ YRRDE 1031_ DWCGG 1036_ RDKLG 1041_ PAAEI 1046_ DHVIP 1051_ LISKH 1056_ LEQKE 1061_ AFLKA 1066_ CTLAR 1071_ RNAEV 1076_ FLKYI 1081_ HRNNV 1086_ SMPSV 1091_ ASHTR 1096_ GPEQQ 1101_ VKAIL 1106_ SELLQ 1111_ RENRV 1116_ LHFWT 1121_ LKKRR 1126_ LDQCQ 1131_ QYVVF 1136_ ERSAK 1141_ QALDW 1146_ IQETG 1151_ EFYLS 1156_ THTST 1161_ GETTE 1166_ ETQEL 1171_ LKEYG 1176_ EFRVP 1181_ AKQTK 1186_ EKVKL 1191_ LIQLA 1196_ DSFVE 1201_ KGHIH 1206_ ATEIR 1211_ KWVTT 1216_ VDKHY 1221_ RDFSL 1226_ RMGKY 1231_ RYSLE 1236_ KALGV 1241_ NTEDN 1246_ KDLEL 1251_ DIIPA 1256_ SLSDR 1261_ EVKLR 1266_ DANHE 1271_ VNEEK 1276_ RKSAR 1281_ KKEFI 1286_ MAELL 1291_ QTEKA 1296_ YVRDL 1301_ HECLE 1306_ TYLWE 1311_ MTSGV 1316_ EEIPP 1321_ GILNK 1326_ EHIIF 1331_ GNIQE 1336_ IYDFH 1341_ NNIFL 1346_ KELEK 1351_ YEQLP 1356_ EDVGH 1361_ CFVTW 1366_ ADKFQ 1371_ MYVTY 1376_ CKNKP 1381_ DSNQL 1386_ ILEHA 1391_ GTFFD 1396_ EIQQR 1401_ HGLAN 1406_ SISSY 1411_ LIKPV 1416_ QRITK 1421_ YQLLL 1426_ KELLT 1431_ CCEEG 1436_ KGELK 1441_ DGLEV 1446_ MLSVP 1451_ KKAND 1456_ AMHVS 1461_ MLEGF 1466_ DENLD 1471_ VQGEL 1476_ ILQDA 1481_ FQVWD 1486_ PKSLI 1491_ RKGRE 1496_ RHLFL 1501_ FEISL 1506_ VFSKE 1511_ IKDSS 1516_ GHTKY 1521_ VYKNK 1526_ LLTSE 1531_ LGVTE 1536_ HVEGD 1541_ PCKFA 1546_ LWSGR 1551_ TPSSD 1556_ NKTVL 1561_ KASNI 1566_ ETKQE 1571_ WIKNI 1576_ REVIQ 1581_ ERIIH 1586_ LKGAL 1591_ KEPLQ 1596_ LPKTP 1601_ AKQRN 1606_ NSKRD 1611_ GVEDI 1616_ DSQGD 1621_ GSSQP 1626_ DTISI 1631_ ASRTS 1636_ QNTVD 1641_ SDKLS 1646_ GGCEL 1651_ TVVLQ 1656_ DFSAG 1661_ HSSEL 1666_ TIQVG 1671_ QTVEL 1676_ LERPS 1681_ ERPGW 1686_ CLVRT 1691_ TERSP 1696_ PLEGL 1701_ VPSSA 1706_ LCISH 1711_ SRSSV 1716_ EMDCF 1721_ FPLVK 1726_ DAYSH 1731_ SSSEN 1736_ GGKSE 1741_ SVANL 1746_ QAQPS 1751_ LNSIH 1756_ SSPGP 1761_ KRSTN 1766_ TLKKW 1771_ LTSPV 1776_ RRLNS 1781_ GKADG 1786_ NIKKQ 1791_ KKVRD 1796_ GRKSF 1801_ DLGSP 1806_ KPGDE 1811_ TTPQG 1816_ DSADE 1821_ KSKKG 1826_ WGEDE 1831_ PDEES 1836_ HTPLP 1841_ PPMKI 1846_ FDNDP 1851_ TQDEM 1856_ SSSLL 1861_ AARQA 1866_ STEVP 1871_ TAADL 1876_ VNAIE 1881_ KLVKN 1886_ KLSLE 1891_ GSSYR 1896_ GSLKD 1901_ PAGCL 1906_ NEGMA 1911_ PPTPP 1916_ KNPEE 1921_ EQKAK 1926_ ALRGR 1931_ MFVLN 1936_ ELVQT 1941_ EKDYV 1946_ KDLGI 1951_ VVEGF 1956_ MKRIE 1961_ EKGVP 1966_ EDMRG 1971_ KDKIV 1976_ FGNIH 1981_ QIYDW 1986_ HKDFF 1991_ LAELE 1996_ KCIQE 2001_ QDRLA 2006_ QLFIK 2011_ HERKL 2016_ HIYVW 2021_ YCQNK 2026_ PRSEY 2031_ IVAEY 2036_ DAYFE 2041_ EVKQE 2046_ INQRL 2051_ TLSDF 2056_ LIKPI 2061_ QRITK 2066_ YQLLL 2071_ KDFLR 2076_ YSEKA 2081_ GLECS 2086_ DIEKA 2091_ VELMC 2096_ LVPKR 2101_ CNDMM 2106_ NLGRL 2111_ QGFEG 2116_ TLTAQ 2121_ GKLLQ 2126_ QDTFY 2131_ VIELD 2136_ AGMQS 2141_ RTKER 2146_ RVFLF 2151_ EQIVI 2156_ FSELL 2161_ RKGSL 2166_ TPGYM 2171_ FKRSI 2176_ KMNYL 2181_ VLEEN 2186_ VDNDP 2191_ CKFAL 2196_ MNRET 2201_ SERVV 2206_ LQAAN 2211_ ADIQQ 2216_ AWVQD 2221_ INQVL 2226_ ETQRD 2231_ FLNAL 2236_ QSPIE 2241_ YQRKE 2246_ RSTAV 2251_ MRSQP 2256_ ARLPQ 2261_ ASPRP 2266_ YSSVP 2271_ AGSEK 2276_ PPKGS 2281_ SYNPP 2286_ LPPLK 2291_ ISTSN 2296_ GSPGF 2301_ EYHQP 2306_ GDKFE 2311_ ASKQN 2316_ DLGGC 2321_ NGTSS 2326_ MAVIK 2331_ DYYAL 2336_ KENEI 2341_ CVSQG 2346_ EVVQV 2351_ LAVNQ 2356_ QNMCL 2361_ VYQPA 2366_ SDHSP 2371_ AAEGW 2376_ VPGSI 2381_ LAPLT 2386_ KATAA 2391_ ESSDG 2396_ SIKKS 2401_ CSWHT 2406_ LRMRK 2411_ RAEVE 2416_ NTGKN 2421_ EATGP 2426_ RKPKD 2431_ ILGNK 2436_ VSVKE 2441_ TNSSE 2446_ ESECD 2451_ DLDPN 2456_ TSMEI 2461_ LNPNF 2466_ IQEVA 2471_ PEFLV 2476_ PLVDV 2481_ TCLLG 2486_ DTVIL 2491_ QCKVC 2496_ GRPKP 2501_ TITWK 2506_ GPDQN 2511_ ILDTD 2516_ NSSAT 2521_ YTVSS 2526_ CDSGE 2531_ ITLKI 2536_ CNLMP 2541_ QDSGI 2546_ YTCIA 2551_ TNDHG 2556_ TTSTS 2561_ ATVKV 2566_ QGVPA 2571_ APNRP 2576_ IAQER 2581_ SCTSV 2586_ ILRWL 2591_ PPSST 2596_ GNCTI 2601_ SGYTV 2606_ EYREE 2611_ GSQIW 2616_ QQSVA 2621_ STLDT 2626_ YLVIE 2631_ DLSPG 2636_ CPYQF 2641_ RVSAS 2646_ NPWGI 2651_ SLPSE 2656_ PSEFV 2661_ RLPEY 2666_ DAAAD 2671_ GATIS 2676_ WKENF 2681_ DSAYT 2686_ ELNEI 2691_ GRGRF 2696_ SIVKK 2701_ CIHKA 2706_ TRKDV 2711_ AVKFV 2716_ SKKMK 2721_ KKEQA 2726_ AHEAA 2731_ LLQHL 2736_ QHPQY 2741_ ITLHD 2746_ TYESP 2751_ TSYIL 2756_ ILELM 2761_ DDGRL 2766_ LDYLM 2771_ NHDEL 2776_ MEEKV 2781_ AFYIR 2786_ DIMEA 2791_ LQYLH 2796_ NCRVA 2801_ HLDIK 2806_ PENLL 2811_ IDLRI 2816_ PVPRV 2821_ KLIDL 2826_ EDAVQ 2831_ ISGHF 2836_ HIHHL 2841_ LGNPE 2846_ FAAPE 2851_ VIQGI 2856_ PVSLG 2861_ TDIWS 2866_ IGVLT 2871_ YVMLS 2876_ GVSPF 2881_ LDESK 2886_ EETCI 2891_ NVCRV 2896_ DFSFP 2901_ HEYFC 2906_ GVSNA 2911_ ARDFI 2916_ NVILQ 2921_ EDFRR 2926_ RPTAA 2931_ TCLQH 2936_ PWLQP 2941_ HNGSY 2946_ SKIPL 2951_ DTSRL 2956_ ACFIE 2961_ RRKHQ 2966_ NDVRP 2971_ IPNVK 2976_ SYIVN 2981_RVNQG
1: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity