Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16)
1_MATPA 6_ GLERW 11_ VQDEL 16_ HSVLG 21_ LSERH 26_ VAQFL 31_ IGTAQ 36_ RCTSA 41_ EEFVQ 46_ RLRDT 51_ DTLDL 56_ SGPAR 61_ DFALR 66_ LWNKV 71_ PRKAV 76_ VEKPA 81_ RAAER 86_ EARAL 91_ LEKNR 96_ SYRLL 101_ EDSEE 106_ SSEET 111_ VSRAG 116_ SSLQK 121_ KRKKR 126_ KHLRK 131_ KREEE 136_ EEEEA 141_ SEKGK 146_ KKTGG 151_ SKQQT 156_ EKPES 161_ EDEWE 166_ RTERE 171_ RLQDL 176_ EERDA 181_ FAERV 186_ RQRDK 191_ DRTRN 196_ VLERS 201_ DKKAY 206_ EEAQK 211_ RLKMA 216_ EEDRK 221_ AMVPE 226_ LRKKS 231_ RREYL 236_ AKRER 241_ EKLED 246_ LEAEL 251_ ADEEF 256_ LFGDV 261_ ELSRH 266_ ERQEL 271_ KYKRR 276_ VRDLA 281_ REYRA 286_ AGEQE 291_ KLEAT 296_ NRYHM 301_ PKETR 306_ GQPAR 311_ AVDLV 316_ EEESG 321_ APGEE 326_ QRRWE 331_ EARLG 336_ AASLK 341_ FGARD 346_ AASQE 351_ PKYQL 356_ VLEEE 361_ ETIEF 366_ VRATQ 371_ LQGDE 376_ EPSAP 381_ PTSTQ 386_ AQQKE 391_ SIQAV 396_ RRSLP 401_ VFPFR 406_ EELLA 411_ AIANH 416_ QVLII 421_ EGETG 426_ SGKTT 431_ QIPQY 436_ LFEEG 441_ YTNKG 446_ MKIAC 451_ TQPRR 456_ VAAMS 461_ VAARV 466_ AREMG 471_ VKLGN 476_ EVGYS 481_ IRFED 486_ CTSER 491_ TVLRY 496_ MTDGM 501_ LLREF 506_ LSEPD 511_ LASYS 516_ VVMVD 521_ EAHER 526_ TLHTD 531_ ILFGL 536_ IKDVA 541_ RFRPE 546_ LKVLV 551_ ASATM 556_ DTARF 561_ STFFD 566_ DAPVF 571_ RIPGR 576_ RFPVD 581_ IFYTK 586_ APEAD 591_ YLEAC 596_ VVSVL 601_ QIHVT 606_ QPPGD 611_ ILVFL 616_ TGQEE 621_ IEAAC 626_ EMLQD 631_ RCRRL 636_ GSKIR 641_ ELLVL 646_ PIYAN 651_ LPSDM 656_ QARIF 661_ QPTPP 666_ GARKV 671_ VVATN 676_ IAETS 681_ LTIEG 686_ IIYVL 691_ DPGFC 696_ KQKSY 701_ NPRTG 706_ MESLT 711_ VTPCS 716_ KASAN 721_ QRAGR 726_ AGRVA 731_ AGKCF 736_ RLYTA 741_ WAYQH 746_ ELEET 751_ TVPEI 756_ QRTSL 761_ GNVVL 766_ LLKSL 771_ GIHDL 776_ MHFDF 781_ LDPPP 786_ YETLL 791_ LALEQ 796_ LYALG 801_ ALNHL 806_ GELTT 811_ SGRKM 816_ AELPV 821_ DPMLS 826_ KMILA 831_ SEKYS 836_ CSEEI 841_ LTVAA 846_ MLSVN 851_ NSIFY 856_ RPKDK 861_ VVHAD 866_ NARVN 871_ FFLPG 876_ GDHLV 881_ LLNVY 886_ TQWAE 891_ SGYSS 896_ QWCYE 901_ NFVQF 906_ RSMRR 911_ ARDVR 916_ EQLEG 921_ LLERV 926_ EVGLS 931_ SCQGD 936_ YIRVR 941_ KAITA 946_ GYFYH 951_ TARLT 956_ RSGYR 961_ TVKQQ 966_ QTVFI 971_ HPNSS 976_ LFEQQ 981_ PRWLL 986_ YHELV 991_ LTTKE 996_ FMRQV 1001_ LEIES 1006_ SWLLE 1011_ VAPHY 1016_ YKAKE 1021_ LEDPH 1026_ AKKMP 1031_ KKIGK 1036_TREEL
1: Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596)