Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]
1_MYRPA 6_ RVTST 11_ SRFLN 16_ PYVVC 21_ FIVVA 26_ GVVIL 31_ AVTIA 36_ LLVYF 41_ LAFDQ 46_ KSYFY 51_ RSSFQ 56_ LLNVE 61_ YNSQL 66_ NSPAT 71_ QEYRT 76_ LSGRI 81_ ESLIT 86_ KTFKE 91_ SNLRN 96_ QFIRA 101_ HVAKL 106_ RQDGS 111_ GVRAD 116_ VVMKF 121_ QFTRN 126_ NNGAS 131_ MKSRI 136_ ESVLR 141_ QMLNN 146_ SGNLE 151_ INPST 156_ EITSL 161_ TDQAA 166_ ANWLI 171_ NECGA 176_ GPDLI 181_ TLSEQ 186_ RILGG 191_ TEAEE 196_ GSWPW 201_ QVSLR 206_ LNNAH 211_ HCGGS 216_ LINNM 221_ WILTA 226_ AHCFR 231_ SNSNP 236_ RDWIA 241_ TSGIS 246_ TTFPK 251_ LRMRV 256_ RNILI 261_ HNNYK 266_ SATHE 271_ NDIAL 276_ VRLEN 281_ SVTFT 286_ KDIHS 291_ VCLPA 296_ ATQNI 301_ PPGST 306_ AYVTG 311_ WGAQE 316_ YAGHT 321_ VPELR 326_ QGQVR 331_ IISND 336_ VCNAP 341_ HSYNG 346_ AILSG 351_ MLCAG 356_ VPQGG 361_ VDACQ 366_ GDSGG 371_ PLVQE 376_ DSRRL 381_ WFIVG 386_ IVSWG 391_ DQCGL 396_ PDKPG 401_ VYTRV 406_ TAYLD 411_WIRQQ
1: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate